Dissertation > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension

The Safety and Effiicacy of Enapril-Hydrochlorothiazide Di-spersible Tablets in Patients with 1st, 2nd Degree Essential Hypertention

Author MaZuo
Tutor LiZhanQuan
School Dalian Medical University
Course Internal Medicine
Keywords Essential hypertension dispersible tablet Enalapril Hydrochlorothiazide
CLC R544.1
Type Master's thesis
Year 2006
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Objective:In this study, by observing the change of blood pressure with time, clinical complications and biochemical indexes change by enalapril- hydrochlorothiazide in patients with 1st, 2nd degree essential hypertention(EH), we evaluated the efficacy and safety of enalapril- hydrochlorothiazide dispersible tablets. Method:Patient selection:There were 130 patients with EH in our hospital outpatient service and communities attending this study. We obtained informed written consent from patients after explaining the procedure and risk. Patients from 18 to 70 years of age were eligible for inclusion into this study. Their diastolic pressure(DBP) fluctuated between 90mmHg and 110mmHg and systolic pressure(SBP) was below 180mmHg. The following exclusion criteria were required for patient enrollment:①secondary hypertension②arrhythmias such as fibrillation、frequent atrial or ventricular premature beats③chronic heart failure, heart function>2nd degree、a history of AMI or unstable angina pectirus or acute heart failure in recent 3 months④a history of transient ischenic attack(TIA), cerebral apoplexy sequelae in recent 3 months⑤typeⅠDM、uncontrolled typeⅡDM(FBG>200mg/dl)、gout、abnormal uric acid⑥renal function damage、hepatie dysfunction⑦electrolyte disturbances⑧having experimental drugs in recent 4 weeks.

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