Dissertation > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Colorectal tumors

Detection of p53 and APC Gene Mutations in Stool of Colorectal Cancer Patients

Author YuanZuo
Tutor LiJianSheng
School Zhengzhou University
Course Internal Medicine
Keywords colorectal cancer (CRC) stool p53 APC PCR-SSCP
CLC R735.34
Type Master's thesis
Year 2006
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Colorectal cancer (CRC) is the second most common cancer in western countries, and it remains the second leading cause of overall malignant mortality in the United States. People of our country now enjoy a higher standard of living, but because of the westernlize of diet habit, the incidence of CRC rises gradually. The 5-year-survival rate after surgery can reach 90% without metastasis, while it is only 50% with metastasis. Therefore, it is important to make an early diagnosis. The best way to find CRC at early stage includes average risk people screening and high risk people surveillance. In 2003 and 2004, American Gastroenterological Association (AGA) and World Gastroenterology Organization (WGO-OMGE) published the latest guidelines for CRC screening; in 2004 and 2005, American Cancer Society (ACS) published guidelines for CRC early diagnosis; in 2006, American Society for Gastrointestinal Endoscopy (ASGE) published the guideline for CRC screening and surveillance. We can easily find that the screening and surveillance of CRC has been put on the key point. But our country has no the similar guidelines, and the screening for CRC has not been carried out all around.Colorectal carcinogenesis is accompanied by a series of several acquired genetic abnormalities that may be responsible for transitions from normal mucosa to incurable cancer. It is now possible to recover analyzable human DNA from stool and to test for

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