Dissertation
Dissertation > Medicine, health > Neurology and psychiatry > Psychiatry > Schizophrenia

Event-related Potential P300’s Follow-up Study in Schizophrenia Patients

Author GuoFengLian
Tutor YangHong
School Shanxi Medical
Course Psychiatry and Mental Health
Keywords schizophrenic Event-related potential P300 PANSS follow-up study
CLC R749.3
Type Master's thesis
Year 2006
Downloads 55
Quotes 0
Download Dissertation

Objective:To identify the property of Event-related potential P300 by follow-up studying the variability of Event-related potential P300 in schizophrenia patients, so as to provide the neuro-electrophysiological basis for the schizophrenia’s pathogeny, dianosis and treatment. Methods:The Positive and Negative Syndrome Scale(PANSS) and the Event-related potential P300 of Fz、Cz、Pz were recorded in 71 schizophrenics who were in their episode of medication-free or drug-na?ve, during the periods including per-treated, 1-month, 3-month and 6-month. after being treated by resperidone. Event-related potential P300 of Fz、Cz、Pz were also recorded in 71 normal controls .Results:1、In comparison with normal controls, before treating the patients had lower amplitude of P3 and longer latency of P3. During the different periods after treatment , the changes of amplitude and latency in P3 is not significant. 2、The patients before treatment had longer inter-perk latency of P2-N2 at Fz、Cz and larger inter-peak amplitude of P2-N2 at Fz and Pz. During the different period of treatment , the changes of inter-peak latency in P2-N2 is not significant, the inter-peak amplitude of P2-N2 become smaller. The inter-peak amplitude of P2-N2 is significantly smaller when treated for six month than treated before. 3、The patients before treated had smaller inter-peak amplitude of N2-P3 at Cz and Pz. During the different period of treatment , inter-peak amplitude of N2-P3 become larger. But, in comparison with normal controls, it is still smaller. No difference in inter-peak latency of N2-P3 between normal controls and patients before treated. The inter-peak latency of N2-P3 is smaller at Cz、Pz and larger at Fz when treatet for six month than treated before. 4、The patients had lower amplitude of P2 at Cz. No difference in latency of P2 between normal controls and patients before treated. During the different period of treatment , the changes of amplitude and latency of P2 is not significant at Fz and Cz. The latency of P2 is smaller and the amplitude of P2 is larger when treated for six months than treated before at Pz. 5、In patients inter-peak amplitude of P2-N2 at Cz and Pz is positively correlated to the negative symptom score. Others show no correlation to the symptom scores. 6、In patients, the inter-peak amplitude of P2-N2、N2-P3 and the amplitude of P3 and P2 is smaller at Pz than Fz and Cz. 7、During the different period of treatment , the PANSS score gradually decrease. 8、After treated for six months , the decrease of inter-peak amplitude of P2-N2 is positively correlated to the decrease of the negative symptom score.Conclusions:1、There is variation in Event-related potential P300 with schizophrenic, and the variation is related to schizophrenic itself, not the medications. 2、There is variation in the many process of information processing with schizophrenic. 3、Probably parietal lobe damaged more seriously than frontal lobe and central lobule in schizophrenic. 4、The variation degree of amplitude and latency in P3 is not related to the serious of clinical symptoms to some degree. 5、The inter-peak amplitude of P2-N2 is related to the severity of negative symptom to some degree. 6、The

Related Dissertations
More Dissertations