Dissertation
Dissertation > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Colorectal tumors

Experimental Study on the Inhibit Effects of 2-methoxyestradiol(2-ME) on the Liver Metastases of Colonrectal Cancer

Author MaZhenYu
Tutor XingChunGen
School Suzhou University
Course Department of General Surgery
Keywords Nude mice Human colon cancer cell Liver metastases Splenectomy Colorectal neoplasm Neoplasm metastasis Angiogenesis inhibitor Angiogensis inhibitor Radiosensitvity Cell cycle
CLC R735.34
Type Master's thesis
Year 2006
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Part I: The improvement in establishment of a model of human colon cancer liver metastases in nude miceObjective : To establish an animal model imitating clinic liver metastases after curative resection of colorectal cancer and discuss the improvement in establishment of the model . Methods: The human colon cancer cells(HCCC)were injected into the spleen of BALB/c nude mice , then the spleen were resected 5 minutes later. On the20th、 35th、 60th postoperative day, The nude mice were examined pathologically. Results: The incidence of liver metastases was found 90%.No metastases noudle was observed in extrahepatic organs. Histological examination showed that the metastases were poorly differented colon adenocancer. Conclusion: The experimental model is very good for imitating clinic sign of liver metastases after curative resection of colorectal cancer. At the same time, several improvement were made in the establishment of the model.PartII: Experimental study of the inhibit effects of 2-methoxyestradiol(2-ME) on the liver metastases of colon cancerObjective: In this study,we aimed to investigate the effects of angiogenesis inhibitor 2-methoxyestradiol(2-ME)on the liver metastases of

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