Dissertation > Medicine, health > Internal Medicine > Digestive and abdominal diseases

The Study of Clinical Symptoms and the Health-Related Quality of Life(HRQL) in Patients with Functional Gastrointestinal Disorder.

Author SunYanFang
Tutor LiYanQing
School Shandong University
Course Internal Medicine
Keywords gastroesophageal reflux disease (GERD) functional dyspepsia (FD) irritable bowel syndrome (IBS) overlap clinical symptom quality of life
Type Master's thesis
Year 2006
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Objective: The aim of the present study was to investigate the feature of clinical symptoms and the health-related quality of life(HRQL) in patients with functional gastrointestinal disorder (FGID).Methods: We investigated 2016 patients in 3 hospitals in Jinan in a same time period .These patients were diagnosed as GERD、 FD、 IBS、 FD+IBS、 FD+GERD、 IBS+ GERD and FD+IBS+GERD.They were investigated by using a questionaire on gastrointestinal symptoms and HRQL.Result:1.The aetiology of GERD、 FD and IBS is unknown,but overlap is frequent.2. FD+IBS patients were more likely to be female(male vs female =1:1.8).The overall symptom severity was significantly higher in FD+IBS than in FD and IBS alone. (11.4±0.4 vs 8.8±0.3, 8.5±0.8 vs 6.5±0.2 .P<0.01).The scale of HRQL decreased significantly in FD+IBS patients than in FD and IBS patients .3. Reflux symptoms score in NERD+FD was higher than RE+FD (13.8±2.2 vs 10.5±1.9,P<0.01) . NERD+FD causes a more significant impairment in the quality of life than RE+FD.4. IBS-C patients reported significantly more overall GI symptoms when compared to patients with IBS-D(13.5±7.3 vs 10.1±7.8, P<0.01)and were negatively

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