Dissertation
Dissertation > Medicine, health > Surgery > Urology ( urinary and reproductive system diseases) > Kidney disease > Renal failure

Chronic renal failure patients with hyperkalemia and oral medicine decoction correlation analysis

Author LiuTao
Tutor YuRenHuan
School Beijing University of Traditional Chinese Medicine
Course Chinese medicine
Keywords CRF hyperkalemia western medicine Chinese herbal medicine decoction association
CLC R692.5
Type Master's thesis
Year 2011
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Objectives:To research the correlation of Chinese herbal medicine decoction with the level of the serum potassium and the prevalence of the hyperkalemia of the CRF patients.Meanwhile research the correlation of related western medicine in clinical reports, with the level of the serum potassium and the prevalence of the hyperkalemia of the CRF patientsMethods:In the way of retrospective investigation, I collected 152 patients who hospitalized in Renal sections, Xiyuan Hospital of China Academy of Traditional Chinese Medicine from February 2010 to March 2011. I recorded the general conditions (including gender, age, weight, etc.), collected information of the patients’medication in the last week before hospitalization by means of asking them in their first day of their hospitalization and referring their first progress note, recorded their first results of biochemical tests about serum creatinin and serum potassium. Analyzed comprehensively association among the mean of serum potassium and the prevalence of the hyperkalemia with CRF patients’using of different types of the western medicine and Chinese herbal medicine decoction. Compared the association of these types of the medication investigated whether taking Chinese herbal medicine decoction is associated with hyperkalemia and degree of the association. Meature the degree of danger of using these kinds of medicine through the degree of association with the hyperkalemia.Results:1 From stage 3 to stage 5 of CKD, the prevalence of the hyperkalemia and the concentration of the serum potassium rised gradually, by statistically significant difference test (P<0.05).2 Whether in the whole, or in stage3, stage 4, stage 5 respectively, the mean of the serum potassium and the the prevalence of the hyperkalemia of the ACEI/ARB using group is higher than non-using group, by statistically significant difference test (P<0.05).3 There is no significant difference (P>0.05) between Beta blockers using group and non-using group. However, whether in the whole, or in stage3, stage 4, stage 5 respectively, the mean of the serum potassium in Beta blockers’using group has a rising trend than non-using group.4 Whether in the whole, or in stage3, stage 4, stage 5 respectively, there is no significant difference (P>0.05) between recombinant human erythropoietin using group and non-using group. The same as NSAID.55 Whether in the whole, or in stage3, stage 4, stage 5 respectively, there is no significant difference (P>0.05) between Chinese herbal medicine decoction using group and non-using group.6 From the aspect of the contingency ciefficient between using medicine and prevalence of the hyperkalemia, using ACEI or ARB is higher than Beta blockers. In stage 3 of CKD, the prevalence of the hyperkalemia of ACEI/ARB using group is higher than non-using group. While there is no significant difference (P>0.05) between Beta blockers using group and non-using group.Conclusions:1 With the renal function declining, the level of serum potassium and the prevalence of the hyperkalemia rise.2 To the CRF patients, using ACEI/ARB will make the level of serum potassium rise, using this kind of medicine has association with hyperkalemia.3 To the CRF patients, from the aspect of the degree of the association between using medicine and hyperkalemia, using ACEI or ARB is higher than using Beta blockers.4 The CRF patients’using of recombinant human erythropoietin and NSAID will not make the level of serum potassium rise, using these two types of medicine has no association with hyperkalemia.5 The CRF patients’using of Chinese herbal medicine decoction will not make the level of serum potassium rise, using Chinese herbal medicine decoction has no association with hyperkalemia.

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