Dissertation > Medicine, health > Oncology > Genitourinary tumors > Breast tumor

Clinicopathological Significances of ER, PR Epression in Carcinoma of Breast

Author GuoLiYing
Tutor WenHao;ZuoMeiXiang
School Xinjiang Medical University
Course Digest breast Vascular Surgery Center of Pediatric Surgery
Keywords breast cancer Estrogen receptorβ(ERβ) Estrogen receptorα(ERα) Progestin receptor (PR) Clinicopathology
CLC R737.9
Type Master's thesis
Year 2006
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Objective: To study on the expression and clinical significance of estrogen receptor βERβ in breast cancer tissue. Methods:75 cases of primary breast cancer were collected and detected by S-P immunohistochemical for the express of estrogen receptor α ERα, ERβ and Progestin receptor PR with En Vision system. Those data were comparasively analysed for their, clinicopathological characters. Results: The ERP positive rate in 75 primary breast cancer tissues was 82.7%(62/75), and the ERβ was 46. 66% (35/75) in which ERα was positive, too. There was significant correlation between the expressions of ERP and ERα (P<0.05). The expression of ERβ was inversely correlated with histological degrees (P<0.05). The ERP positive rate showed 80%(28/35) in the axillary lymph node positive group, and while 47.5% (19/40) in the negative group, which had significant difference (p<0.05); The ERP positive expression in 45~50 year grade was obviously higher than that in the over year group, and interestingly the left breast was significantly higher than the right breast, p<0.05. Histology II was also showed significantly higher than that of I, p<0.05. The expression of ERβ had no correlation with tumor size, clinical stage and pathological type (P>0.05) Conclusion: (1)ERβ widely expresses in breast cancer tissues; ERP expresses much lower than ERα; Based on ERβ and ERα expresses together, there was no correlation between the

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