Dissertation > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > The Chinese herbal medicine preparations of the production

Study on the Preparation and the Quality Standards in Naotai Tablets

Author YangJing
Tutor XiaXinHua
School Hunan University of Traditional Chinese Medicine
Course Of Pharmacy
Keywords Preparation Process Orthogonal design Alcohol precipitation Separate drying Mixed dry Quality standards
Type Master's thesis
Year 2010
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Objective: To study brain Thai film preparation process and quality standards , on the basis of the preparation and quality control for the treatment of cardiovascular and cerebrovascular diseases preparing a new film coating formulations . Methods : analysis and extraction route filtering through prescription , to determine the extraction process route to tetramethylpyrazine , ferulic acid , the total amount of flavonoids leaching indicators preferred influence leaching factors ; compared by single factor , total flavonoids retention rate indicators , preferably alcohol precipitation process conditions ; comparative experiments investigated alcohol extract separate drying and mixing and drying , and vacuum drying under different temperature conditions tetramethylpyrazine and ferulic acid content ; disintegration indicators , combined with the pelleting process tabletting process parameters, preferred brain Thai piece molding process conditions ; to do qualitative identification using thin layer chromatography ; content was determined by high performance liquid chromatography (HPLC) , and methodological study . Results: Chuanxiong extracted with ethanol , the astragalus , A, B , water extraction . Alcohol extract optimum conditions were : 40% ethanol , heated to reflux extracted two times , plus the amount of alcohol , respectively, to 10,8 times , extraction time were 2,1.5 hours . Water extraction , the optimum conditions of : extracting 3 times, water addition was 10 times that of herbs , eight times , eight times , and extraction time were 2.0 hours , 1.5 hours , 1.5 hours . Reminder water extracting solution was concentrated to a relative density of 1.20 , adding 95 % ethanol , so that liquid containing an alcohol content of 60% , after standing for 24 hours , filtered , and dried with the alcohol extract solution was vacuum 70 ° C mixed . Molding process conditions : drug fine powder : lactose: soluble starch = 14:3:3,3 % PVP ( K30 ) , 95 % ethanol solution as a binder , 0.5% micronized silica gel as a glidant , and 1 % of stearic acid magnesium as a lubricant . Astragalus, Chuanxiong The TLC of negative interference , A and B, TLC of the double negative interference , tetramethylpyrazine and ferulic acid determination method is feasible and reproducible . Conclusion : The preparation process is feasible , reliable and quality standards , and can be used in industrial production .

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