Dissertation > Medicine, health > Oncology > Department of Otolaryngology tumor > Pharyngeal tumors

The Comparative Analysis of Radiotherapeutic Prognosis of Nasopharyngeal Carcinoma According to Chinese 1992, 2008 and UICC2010 Staging Systems

Author WangFengGang
Tutor LuXueGuan
School Suzhou University
Course Oncology
Keywords Nasopharyngeal tumor Installments Radiation therapy Prognosis
CLC R739.63
Type Master's thesis
Year 2011
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Purpose of the current international yet to apply uniform nasopharyngeal clinical staging, enacted in 2008, based on China in the 1992 staging of the 2008 staging criteria, and the International Union Against Cancer (UICC) also released the latest in 2010, the first Seventh Edition of nasopharyngeal cancer staging criteria. However, the very lack of staging the merits comparison between, is not conducive to guide treatment, and to assess the efficacy and academic exchanges between. Retrospective analysis of 347 patients with nasopharyngeal carcinoma patients, comparing nasopharyngeal consistency between the Chinese 1992,2008 and UICC 2010 staging criteria to evaluate their efficacy value in predicting nasopharyngeal carcinoma radiotherapy. Methods A retrospective analysis of the clinical data of 347 patients without distant metastases previously untreated patients with nasopharyngeal carcinoma, T, N, and clinical stage Chinese 1992,2008 and UICC 2010 staging patients. Kappa method to analyze the consistency between the phases of the distribution of the number of cases in the different staging using the Kaplan-Meier method to assess the of three installments standard clinical staging, T and N stage on overall survival, local recurrence-free survival and distant metastasis-free survival, Log-rank test their differences. Between the results of the 2008 staging and UICC 2010 staging clinical stage, T and N stage cases constitute a proportion of consistency are superior to the comparison between each of them with the 1992 installment Kappa values ​​were 0.700, 0.881,0.722; 2008 installments installments UICC2010 standard with the 1992 staging criteria in the clinical stage, T staging, N staging cases constitute the T staging better consistency than comparison Kappa values ​​were 0.570 and 0.548,0.877 and 0.761,0.485 and 0.531. stage and UICC 2010 staging under the standard clinical stage survival curve trend are better than the 1992 installment (χ 2 = 36.30, P = 0.000; χ 2 = 37.73, P = 0.000; χ 2 = 33.19, P = 0.000); 1992 staging in stage Ⅲ and Ⅳ overall survival curves intersect (χ 2 = 0.401, P = 0.526); the three installments standard T1 and T2, T2 and T3, T3 and T4 stage between local recurrence-free survival rates were not statistically different ( the χ 2 = 0.529,0.502,1.849 P = 0.467,0.479,0.174 and the χ 2 = 2.096,1.986,1.248, P = 0.148,0.159,0.264 and, χ < sup> 2 = 0.595,0.873,0.768, P = 0.441,0.350,0.381); 1992 staging the N 0 with N of 1 , N < sub> 1 with N of 2 N 2 with N of 3 were not statistically difference (χ 2. = 3.712,3.113,2.014, P = 0.054,0.078,0.156), 2008 installment standard N 1 with N of 2 , N , 2 significant (χ 2 = 10.488,5.059, P = 0.001,0.024); N 3 between the UICC staging criteria only N 1 and N 2 significant difference between (χ 2 = 7.731, P = 0.0054). Conclusion China the 2008 staging staging and UICC2010 standard cases better than the results of the comparison between their respective and 1992 installments constitute a proportion of consistency. The three installments standard could prompt radiotherapy of nasopharyngeal carcinoma patients, but China from staging and UICC2010 installments standard predict the effect of radiotherapy in patients with nasopharyngeal carcinoma, the results are similar and are significantly better than the 1992 installment.

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