Preparation and Properties of Hydroxyecdysone Microcapsules by Complex Coacervation
|School||Northeast Forestry University|
|Course||Forest Biological Engineering|
|Keywords||Complex coacervation Microcapsules Ecdysone Controlled release Light stability|
Green Pesticide Formulation Development is the focus of current research . Mainly related to the ultra-efficient , low toxicity ( or non-toxic ) , low-residue , environmental pollution , chemical pesticides , hormones pesticides is one of the important direction . Microcapsules as a protection technique , often used in the preparation of the new pesticide . In this paper, selected by orthogonal experimental beta - ecdysone (β-HE) microcapsules best preparation conditions ; using scanning electron microscopy and optical microscopy to characterize the preparation of β-HE microcapsules morphology ; study β-HE micro the capsules release behavior and light stability , and the β - HE microcapsules indoor virulence determination experiment . The main findings are as follows : optimized by single factor and multi-factor orthogonal optimization experiments to determine the system in the wall material concentration of 3% the core wall material ratio of 1:1 , early pH value of 4.6 , the late pH value of 8.0 for β- HE Microencapsulation optimum conditions . Under this condition , the film may be formed wall smooth, uniform size of the spherical microcapsules having an average particle size of 5μm, the drug loading and the covering rate reached 68.5 % and 63.4% respectively . The release behavior of the microcapsules showed that the analog insects enteral under ambient conditions and in simulated field under the environmental conditions , the β - HE microcapsule phase for the normal β-HE has obvious release behavior . Photodegradation experiments , β-HE microencapsulated phase for ordinary p-HE has significant UV resistance , strong light stability . The virulence test experiment , β-HE microcapsules β-HE original drug in the the feeding insects 3 days virulence regression equation : (1) β-HE microcapsules : Y = 11.1221 1.7053x ; LC50 = 0.0024 (2) β-HE original drug : Y = 11.4260 1.7546x ; LC50 of = 0.0022 . Selected in the feeding containing β - HE microcapsules with β-HE original drug 3 days after the insecticidal effect , β - HE microcapsules of the pharmacodynamic effect of holding time is longer , and the insecticidal effect was more significant .