Investigate the Expression of TGFβ1、 TGFβRⅡ、 p27and Cyclin E in the Pathogensis of Condyloma Acuminatum
|School||Huazhong University of Science and Technology|
|Course||Dermatology and Venereology|
|Keywords||Genital warts Transforming growth factor β1 Transforming growth factor β Ⅱ receptor p27 Cyclin E|
Objective : To study the transforming growth factor β1 (TGFβ1), transforming growth factor- β Ⅱ receptor (TGFβR Ⅱ), p27 and cyclin E (Cyclin E) protein in genital warts (CA) tissues . Methods: Immunohistochemistry SP (streptavidin-perosidase) method and the image analysis system to detect 30 cases of patients with genital warts lesions , 15 cases of normal skin ( foreskin ) organization TGFβ1, TGFβR Ⅱ, p27 and Cyclin E expression and distribution . Results : (1) TGFβ1, Cyclin E in condyloma tissues were significantly higher than in normal skin tissue , the difference was statistically significant (P lt; 0.05); (2) TGFβR Ⅱ, p27 in condyloma tissues was significantly lower than normal skin tissue , the difference was statistically significant (P lt; 0.05); (3) TGFβ1 and Cyclin E in condyloma tissues were positively correlated (P lt; 0.05); while TGFβR Ⅱ and Cyclin E in condyloma acuminata expression was negatively correlated (P lt; 0.05); TGFβ1 and p27 in condyloma tissues was negatively correlated (P lt; 0.05); TGFβR Ⅱ and p27 in condyloma tissues were positively correlated (P lt; 0.05 ); p27 and Cyclin E in condyloma tissues was negatively correlated (P lt; 0.05). Conclusion : In the warts tissue TGFβ1 upregulated and downregulated TGFβR Ⅱ , the TGFβ signaling pathway blocked , causing TGFβ1 lack of a negative regulator of cell proliferation promoting effect of p27 protein , and the resulting Cyclin E overexpression leaving the abnormal cell cycle regulation , cell proliferation.