Dissertation > Medicine, health > Obstetrics and Gynaecology > Gynecology > Other diseases of the female genital > Endometriosis

Study on the Expression of Claudin-1 and Claudin-3 in Eutopic、Ectopic Endometrum and Peritoneum of Women with Endometriosis and Its Clinical Significance

Author WangShuXian
Tutor GuoXiaoQing
School Shihezi University
Course Obstetrics and Gynaecology
Keywords Endometriosis Eutopic endometrial Ectopic endometrial Peritoneum claudin-1 claudin-3
CLC R711.71
Type Master's thesis
Year 2010
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Objective: by detecting claudin1, the Endometriosis (Endometriosis, EMs) expression in eutopic endometrium and ectopic endometrium explore claudin1 3 in EMs mechanism; through research claudin1, 3 expression in the peritoneum, a preliminary discussion of the development of the relationship between the peritoneum and endometriosis. Methods: SP immunohistochemical assay EMs patients eutopic endometrium, the ectopic endometrial, endometriotic lesion-containing peritoneal and peripheral visual observation of normal peritoneum in claudin1 3 protein expression in ectopic endometrium taken from the ovaries differences bit intima; The same methods detect the normal control group, endometrial and peritoneal claudin1 3 protein expression. Results: EMs patients eutopic endometrium, ectopic endometrium and normal endometrium can be seen claudin1 moderate positive or strong positive expression of three proteins, but EMs ectopic endometrium in both strong positive rate than the reign of endometrium and control endometrium significantly reduced, and a statistically significant (P lt; 0.01); of EMs endometrial reign the endometrial both strong positive expression rate is slightly lower than that of the control, the difference was not statistically significant (P gt; 0.05). The EMs in patients with ectopic lesions peritoneal, ended often peritoneum and normal control group peritoneal tissue surrounding the naked eye observation, claudin1 positive expression was no significant difference in the the normal peritoneal, and EMs patients normal peritoneal, no statistical significance (P gt; 0.05 ); claudin1 positive expression in EMs patients with normal peritoneal slightly below the with ectopic lesions peritoneal, but the difference was not statistically significance (P gt; 0.05). no significant difference in positive expression of claudin3 ended often in patients with peritoneal and EMs normal peritoneal, no statistical significance (P gt; 0.05); expression was slightly lower than in the EMs patients with normal peritoneal positive claudin3 containing ectopic lesions peritoneal difference statistically significant (P gt; 0.05). claudin1 expression levels with the staging of endometriosis without significantly related to sex (P gt; 0.05). Conclusions: claudin1 3 protein expression in EMs ectopic endometrium of patients significantly down, both may be related to the occurrence and development of EMs, help to the EMs further research; the expression exists claudin1 peritoneal mesothelial cells, 3 protein structure and function may not be changed, easy to grow in the pelvic peritoneum on the correlation of the mechanism need further detailed study and study EMS ectopic endometrium of patients, and from Claudin perspective is the present a new perspective, there are The need for more in-depth research.

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