Dissertation
Dissertation > Medicine, health > Internal Medicine > Systemic disease > Poisoning and chemical damage > Alcohol poisoning

Clinical Study on Determination of the Serum Leptin and Insulin in the Patients with Chronic Alcoholism

Author QuanChunHua
Tutor WuGuang;CuiSongBiao
School Yanbian University
Course Internal Medicine
Keywords Alcoholism Leptin Insulin Metabolic syndrome Cerebrovascular disease
CLC R595.6
Type Master's thesis
Year 2010
Downloads 15
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Objective To investigate the changes of the patients with chronic alcoholism serum leptin, insulin levels, insulin sensitivity and correlation clarify alcoholism occurs, development, outcome and stroke pathological processes and mechanisms for clinical prevention and treatment of alcoholism in patients favorable theoretical basis. Selected 54 cases of patients with chronic alcoholism, are in line with alcohol-induced mental disorder (according to the Chinese classification of mental disorders and the diagnostic criteria of CCMD-3) diagnostic criteria, and drinking history gt; 5 years. Alcoholism group drinking life of 5-10 years group divided into drinking, drinking the 10-20 years group drinking 20-30 years group; CT a merger of brain atrophy and ischemic cerebrovascular disease abnormal CT group divided into alcoholism. CT normal group. And selected 33 cases of healthy control group. Using radioimmunoassay method for the determination of the alcoholism group and the control group, fasting serum leptin and insulin levels, insulin sensitivity index (insulin sensitivity index, ISI) determined according to the subjects' blood sugar and insulin levels, insulin resistance index (insulin resistance, IR) for comparison. Results (1) wine poisoning group serum LP FBG, the SBP, the TC, IR compared with the control group is high, compared to a significant difference (P lt; 0.01); wine poisoning group, the ISI, HDL compared with the control group were significantly reduce, the comparison there is significant difference (P lt; 0.001). Liquor poisoning group INS, TG, LDL, DBP and control group showed no significant difference (P gt; 0.05). (2) With the increase of the drinking years, alcohol poisoning serum LP, INS increased, the ISI values ??decrease, IR increases. Alcohol poisoning drinking 5-10 years group, alcohol poisoning drinking the 10-20 years group, alcohol poisoning drinking the 20-30 years group and control group, four groups LP INS was no significant difference (P gt; 0.05), ISI, IR, compare were statistically significant (P lt; 0.01, P lt; 0.05). 5-10 years group alcohol poisoning drinking, alcohol poisoning drinking the 10-20 years group, alcohol poisoning drinking the 20-30 years group that ISI were lower than the control group, significant differences (P lt; 0.05); the wine poisoning drinking 10-20 year group, alcohol poisoning drinking 20-30 IR group and the control group there was a significant difference (P lt; 0.05). (3) alcohol poisoning group prevalence of diabetes is higher than that in control group, significant differences (P lt; 0.001); alcohol intoxication group metabolic syndrome, high TC hyperlipidemia, central obesity, hypertension prevalence in the control group more significant difference (P lt; 0.01); alcoholism group overall prevalence of obesity was significantly lower than the control group, compared to a significant difference (P lt; 0.001). (4) wine poisoning group BMI was significantly lower than the control group, the more significant difference (P lt; 0.01). WHR, WHtR, WC of alcohol intoxication group with the control group showed no significant difference. (5) alcoholism abnormal CT group, alcohol poisoning serum LP normal CT and control groups among the three groups, the ISI, there were significant differences (P lt; 0.05), serum INS was no significant difference (P gt; 0.05). The CT abnormalities group alcohol poisoning, alcohol poisoning, normal CT group and the control group, serum LP were significantly different (P lt; 0.05). Alcohol poisoning CT abnormalities group, alcohol poisoning serum ISI normal CT group and the control group were significantly different (P lt; 0.01). Conclusions (1) long-term drinking can increase the level of serum LP, and serum LP level was negatively correlated with ISI, INS, IR was positively correlated with the drinking of years. (2) Drinking can increase the metabolic syndrome and diabetes, hypertension, hyperlipidemia, disease prevalence. (3) long-term drinkers increased serum LP levels caused ISI reduce, to participate in the formation of the IR, this may be one of the pathogenesis of cerebrovascular disease alcoholism.

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