Dissertation > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology

Research of the Effect of PQS on the Expression of Caspase-8 and Caspase-9 on Cerebral Ischemia

Author ZhangYan
Tutor SuYunMing;GuanLiXin
School Heilongjiang University of Traditional Chinese Medicine
Course Pharmacology
Keywords Panax quinquefolius saponin Cerebral ischemia Apoptosis Caspase-8 Caspase-9
CLC R285.5
Type Master's thesis
Year 2010
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The purpose of the research the Panax quinquefolius saponins (PQS) Caspase-8 and Caspase-9 expression after focal cerebral ischemia , and further explore its mechanism . Methods suture method blocking one side of the brain of rats artery ( MCA ) Preparation of focal cerebral ischemia model , after modeling to detect the following indicators : neurological symptom score ① Press Longa Law , light microscopy neuropathology morphological changes ; ② RT-PCR to detect the cerebral cortex of apoptosis-related gene caspase -8 , Caspase - 9 mRNA expression . Results PQS significantly improve the neurological deficits signs of focal cerebral ischemia in rats , reducing neurological deficit scores , reduce pathological changes . 2.PQS can significantly reduce focal cerebral ischemia in rat brain tissue apoptosis related gene caspase -8 expression of Caspase - 9 mRNA expression . Conclusion panax quinquefolius saponin on focal cerebral ischemia has a protective effect , the mechanism may panax quinquefolius saponin inhibition of neuronal apoptosis .

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