Anti-fibrosis Effect of Du Yiwei Granule on Rats with Hepatic Fibrosis
|School||Chengdu University of Traditional Chinese Medicine|
|Course||Chinese medical science|
|Keywords||Kudo particles Liver fibrosis Procollagen type Ⅲ Hyaluronic acid|
Purpose Kudo particles by observing the therapeutic effect on experimental liver injury in rats to explore its to improve the function of the liver cells , control dummy Ye Shengcheng efficacy , which to clarify Duyiwei Liver Liver mechanism Kudo in clinical liver fiber treatment in the application of modern scientific basis . Methods 60 SD rats were randomly divided into six groups , namely the normal control group , model group, colchicine group , the Kudo particles high dose group , middle dose group and low dose group , high-fat to carbon tetrachloride oil joint the diet composite factors liver fibrosis model , modeling the same time , I consecutive treatment for each dose group , normal control group , model group were given normal saline , modeling and administration during the detailed observation of each group of rats in general , experiments in the sixth week after the expiration of 24 hours of fasting , femoral artery blood serum samples to detect the rats liver function ALT , AST of MAO and liver fiber index PC Ⅲ , HA , at the same time taken and other parts of the same amount pathological changes in liver tissue pathology sections were stained rat liver . The results are compared with model group , other than Kudo particle low-dose group can reduce the serum levels of AST ( P lt; 0.05 ) , all the medicated group was significantly lower serum ALT , AST , MAO content (P lt; 0.01); in addition to Kudo in serum PC Ⅲ level of the low- dose group , although a certain level of decline , but no significant differences ( P gt ; 0.05) , all the medicated group significantly decreased serum PC Ⅲ HA content (P lt ; 0.0 1 ) ; Kudo the particle dose group compared with the model group , liver fibrosis decreased significantly ( P lt; 0.01 ) . Colchicine group Duyiwei each group compared with no significant difference ( P gt ; 0.05) . Conclusion Duyiwei particles can effectively reduce the pathological changes of liver fibrosis in rats , improve liver function, so that the decline in the degree of liver fibrosis , have better hepatic fibrosis .