Dissertation > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology

Anti-fibrosis Effect of Du Yiwei Granule on Rats with Hepatic Fibrosis

Author YangZuo
Tutor TanWanChu
School Chengdu University of Traditional Chinese Medicine
Course Chinese medical science
Keywords Kudo particles Liver fibrosis Procollagen type Ⅲ Hyaluronic acid
CLC R285.5
Type Master's thesis
Year 2010
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Purpose Kudo particles by observing the therapeutic effect on experimental liver injury in rats to explore its to improve the function of the liver cells , control dummy Ye Shengcheng efficacy , which to clarify Duyiwei Liver Liver mechanism Kudo in clinical liver fiber treatment in the application of modern scientific basis . Methods 60 SD rats were randomly divided into six groups , namely the normal control group , model group, colchicine group , the Kudo particles high dose group , middle dose group and low dose group , high-fat to carbon tetrachloride oil joint the diet composite factors liver fibrosis model , modeling the same time , I consecutive treatment for each dose group , normal control group , model group were given normal saline , modeling and administration during the detailed observation of each group of rats in general , experiments in the sixth week after the expiration of 24 hours of fasting , femoral artery blood serum samples to detect the rats liver function ALT , AST of MAO and liver fiber index PC Ⅲ , HA , at the same time taken and other parts of the same amount pathological changes in liver tissue pathology sections were stained rat liver . The results are compared with model group , other than Kudo particle low-dose group can reduce the serum levels of AST ( P lt; 0.05 ) , all the medicated group was significantly lower serum ALT , AST , MAO content (P lt; 0.01); in addition to Kudo in serum PC Ⅲ level of the low- dose group , although a certain level of decline , but no significant differences ( P gt ; 0.05) , all the medicated group significantly decreased serum PC Ⅲ HA content (P lt ; 0.0 1 ) ; Kudo the particle dose group compared with the model group , liver fibrosis decreased significantly ( P lt; 0.01 ) . Colchicine group Duyiwei each group compared with no significant difference ( P gt ; 0.05) . Conclusion Duyiwei particles can effectively reduce the pathological changes of liver fibrosis in rats , improve liver function, so that the decline in the degree of liver fibrosis , have better hepatic fibrosis .

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