Dissertation
Dissertation > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology

She Gan Ma Huang Tang and Kidney Drugs on IL-10, LXA4

Author YiHong
Tutor LiuXiaoFan
School Chengdu University of Traditional Chinese Medicine
Course Chinese Academy of Pediatrics
Keywords asthma Shegan Ephedra Decoction Kidney drug IL-10 LXA4 animal model
CLC R285.5
Type Master's thesis
Year 2010
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Objective:This study was replicated in mouse asthma models, with Shegan Ephedra Decoction and kidney drug intervention to IL-10, LXA4 as observation indicators, Shegan Ephedra Decoction and kidney of drugs on the inflammatory process of the anti-regulatory mechanism, namely, by stimulating within endogenous anti-inflammatory approach to control inflammation of the purpose, rather than just a variety of pro-inflammatory media antagonism, which can provide new ideas for the treatment of asthma. Some other modern Chinese scholars believe that asthma is a kidney mass, asthma, acute exacerbation of the existence of varying degrees of disease kidney machine, made by dispelling evil and the exacerbation of kidney and facilities of the therapies can increase the treatment, the experimental attempt to verify the theory.Methodology:With healthy and clean male BALB/C mice were randomly divided into normal control group, asthma group, Shegan Ephedra Decoction small-dose group, Shegan Ephedra Decoction high-dose group, Shegan Ephedra Decoction with kidney drugs small-dose group, Shegan Ephedra Decoction with kidney drugs high-dose group 7 groups, the first 1,7,14 day as the normal control group were given physiological saline, the remaining liquid were injected intraperitoneally to establish asthma model, the first 21 days of continuous use atomizer lOd, except normal control group with saline spray, the rest were with 1%ovalbumin aerosol, each day, every 30 min. Mice administered 30min before stimulation every time. End of the experiment with a heart blood method to take blood samples, using double-antibody sandwich ELISA method detected IL-10 levels by enzyme-linked immunosorbent assay (ELISA method) detection LXA4.Results:1. Comparing with the blank group, every IL-10 curing group serum rises obviously, has statistics meaning except that the model group obvious serum IL-10 lessening; Comparing with model collation group, every contents curing group serum IL-10 rise obviously, have obvious statistics meaning; The group compares with low dosages of SheGan ephedra soup, three set of traditional Chinese medicine cure group serum IL-10 other curing a group lower than here, group difference has statistics meaning. Give exegesis or explanation:p<0.05, the difference of groups has statistics meaning.2. Comparing with the blank group, the model forms serum LXA4 contents coming down obvioursly, has the notable difference; Comparing with model collation group, every contents curing group serum LXA4 rise obviously, have obvious statistics meaning. Give exegesis or explanation:P<0.05, the difference of groups has statistics meaning.Conclusions:1. Shegan Ephedra Decoction and it with kidney nourishing kidney herb can boost inner source nature resisting scorching medium, have obvious restrain imflammation resisting scorching effect, process has opposing the adjustment effect to the inflammation.2.Low dosages of Shegan Ephedra Decoction is better than Shegan Ephedra Decoction nourishing kidney low dosages,but the difference between two high dosages of SheGan ephedra Decoction and it with nourishing kidney herb is not obvious, To add nourishes kidney or not need further experiment demonstration while impatient scheduled time of asthma

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