Dissertation
Dissertation > Medicine, health > Chinese Medicine > Chinese medicine clinic > Acupuncture, acupuncture therapy

Experimental Study of Acupuncture Preconditioning Effect on Ultrastructure and Apoptosis of Rat’s Brain Ischemia

Author DanLiLi
Tutor SunZhongRen
School Heilongjiang University of Traditional Chinese Medicine
Course Acupuncture and Massage
Keywords Cerebral ischemic preconditioning Ischemic tolerance Acupuncture preconditioning Global cerebral ischemia Apoptosis
CLC R245
Type Master's thesis
Year 2003
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In order to explore new ways of prevention and treatment of ischemic cerebrovascular disease , reveal the mechanism of acupuncture prevention of ischemic stroke , to Wistar rats as subjects , cerebral ischemia treated with acupuncture , the use of \established rat model of cerebral ischemia , cerebral ischemia cerebral cortex , the hippocampus CA 1 < / sub > District HE staining of histological changes , nerve cells Nissl special methylene blue staining of nerve cell damage , electron microscopy ultrastructure of apoptosis in situ end labeling (TUNEL staining) was detected neuronal apoptosis . Experimental results show that : Compared with the normal group , sham operation group , cerebral ischemia group cerebral cortex, the hippocampus CA 1 < / sub > District nerve cell loss significantly . Compared with cerebral ischemia group , cerebral ischemia preconditioning group, acupuncture preconditioning group , electro-acupuncture preconditioning group cerebral cortex , the hippocampus CA 1 < / sub > District neuronal injury is small, light degree of edema , neurological cell morphology and rapid recovery , less the number of apoptotic cells , the EA preconditioning group with cerebral ischemic preconditioning group similar , but better than acupuncture preconditioning group . Conclusion: Acupuncture Preconditioning , the hippocampus CA 1 < / sub > District nerve cells has a protective effect against cerebral ischemic rat cerebral cortex ; acupuncture preconditioning can inhibit global cerebral ischemia in rat cerebral cortex , hippocampus CA 1 < / sub > District neuronal apoptosis ; acupuncture can be used as the means of a cerebral ischemic preconditioning can induce ischemic tolerance , reduce neuronal injury after ischemia .

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