Exploration of the Relationship between HLA-DRB1 Locus and Systematic Lupus Erythematosus of the Zhuang Nationality in Guangxi
|School||Guangxi Medical University|
|Keywords||Zhuang Guangxi Erythematosus Systemic polymerase chain reaction - sequence specific primers HLA-DRB1|
Objective: To investigate the correlation of the Guangxi Zhuang systemic lupus erythematosus (SLE) patients with the HLA-DRB1 gene . Methods : using the polymerase chain reaction - sequence specific primers (PCR-SSP) method , comparative study of 52 cases of the Zhuang SLE patients and 70 the Zhuang healthy by HLA-DRB1 gene . Results : SLE patients group HLA-DRB1 * 1401 and DRB1 * 16 allele frequency lower than the normal control group (RR = 0.2813, x ~ 2 = 5.0024, P = 0.0252 and RR = .3889 x to 2 = 3.9527 , P = 0.0466 ) , the SLE group and normal control group was not detected in the HLA-DRB1 * 08, DRB1 * 11 and DRB1 * 13 allele . Conclusion: HLA-DRB1 * 1401 and DRB1 * 16 allele may be protective gene Guangxi Zhuang SLE susceptibility genes not found in the HLA-DRB1 seat .