Dissertation > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology

Experimental Study of SSHZWY on the Gastro-intestinal’ Hormone in Treating Chronic Atrophic Gastritis Rats

Author ZhangPing
Tutor DongYuXiang
School Jilin University
Course Traditional Chinese Medicine
Keywords Chronic atrophic gastritis Sshzwy Animal model gastrointestinal hormone Pathogenesis Treatment
CLC R285
Type Master's thesis
Year 2004
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Chronic atrophic gastritis (CAG) is a common disease and with no definite pathogeny and pathogenesis. With the development of the technology and progress of making animal models, the pathogenesis of CAG has been thought connected with following factors: environment, immunity, heredity, bile reflux, HP infection, etc. During the recent years, CAG has been thought an effective relationship with the disturbance of neuroendocrine and the research for the gastrointestinal hormone has been performed more and more. The disturbed excretion of gastric and intestinal hormone have been proved one of the primary etiologic factors by quantities of medical literature. Modern medicine often use protecting gastric mucosa, cleaning away HP, increasing the motivation of stomach to cure CAG. Chinese medicine is suitable for long-term administration and has the character of nimbleness and fewer side-effect and has attained the goal of better cure. San shen Zi Wei Yin (Sshzwy) is a Compound Chinese drug manufactured by our department on curing CAG and has made a great progress. In order to perform basic research, we have succeed in making CAG animal models in wistar rats and observed the change of neuroendocrine for each group-normal group, model group, WMS group, large-dose-Sshzwy- administrated group, normal-dose-Sshzwy-administratedgroup, little- dose-Sshzwy-administrated group, and trying to study the neuroendocrine mechanism of pathogeny and the treatment <WP=42>mechanism. We got blood 4ml from abdominal aorta of wistar rats and mensurated the GAS and MTL. We got 1/3 stomachs, scraped the mucosa and mensurated SS and PGE2 with the method of radiation-immunity technology. The data was analysed with SAS soft ware and the result was obtained: SS, MTL and PGE2 in model group were effectively lower than those in normal group (P<0.05) and GAS was higher (P<0.05). All the rats were administrated for 40 days and the indexes in each group rose or fell, especially in normal-dose-Sshzwy-administrated group and little-dose-Sshzwy-administrated group. The result suggest that the rats suffered from CAG have the disturbance of the hormone of stomach and intestine: SS and PGE2 fell in stomach mucosa; GAS rose evidently and MTH activated less in the round circulation. WMS and SShzwy, especially SShzwy can modulate the disturbance. Gastrointestinal gut is a large and complicated endocrinal organ and its activities were modulated by gastrointestinal nerve system and blood-fluid system. The Gastrointestinal hormone has both effectiveness, it can not only modulate the movement of stomach and intestine by releasing the hormone but can also do it by releasing neurotransmitter. GAS and SS can restrict each other and SS can restrain the secretion of GAS by paracrine. The disturbance of them can make great effect to the digestive system even all the other system of the body. GAS can stimulate the exocrine of gastric acid, pepsin, pamcreatin, promote the contract of gastric antrum, increase the blood fluid of gastric mucosa. It can also promote the cleavage and <WP=43>proliferation of the gastrointestinal cells, increase the synthesis of DNA and RNA, expedite the regenerate of gastrointestinal mucosa. Malignant cells are more sensitive to GAS, the high concentration of GAS can promote the proliferation of them. Growth hormone release inhibiting hormone is a kind of gastrointestinal hormone with great biological activity and has an effectiveness of suppress. It can reduce the secretion of gastric acid, pepsin, pamcreatin and suppress the exhaustion of stomach and the peristalsis of intestine. It can also suppress the absorption of the intestine and the secretion of gastrin. In our study, the rats with CAG have the disturbance of the proportion between GAS and SS and this suggests the disturbance is one of the etiological mechanisms of CAG. WMS and SShzwy can both modulate the disturbance and lower the level of GAS and MWS is more effective than SShzwy. For the promotion of SS, normal-dose-Sshzwy-administrated group and little-dose

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