Dissertation > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > The Chinese herbal medicine preparations of the production

The chemometric algorithm in the study of TCM fingerprint

Author HuZuo
Tutor LiangYiZeng
School Central South University
Course Analytical Chemistry
Keywords Chemometrics TCM fingerprint Multicomponent Spectral Correlative Chromatography Erigeron Chemical Pattern Recognition
Type Master's thesis
Year 2004
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With the continuous advancement of modern analytical techniques , the modernization of traditional Chinese medicine research has been continually developed and depth , which traditional Chinese medicine quality control is at the heart of the modernization of traditional Chinese medicine , industrialization and internationalization . Although Chinese medicines containing the substance group is a very complex issue , but combined with instruments and the rapid development of chemometric methods for the analysis and quality control of Chinese medicine system provides a powerful means and broad prospects . The actual Chinese medicine system for the study of the target , the use of chemometrics methods TCM fingerprint analysis and quality control of TCM . The first chapter deals with the recent development of Chinese medicine quality control mode , as well as traditional Chinese medicine fingerprint , modern analytical techniques and chemometric methods in quality control of traditional Chinese medicine . Chapter II have the same spectrum, based on the same chemical substances in the single component spectra chromatography based on the proposed new method of multicomponent spectra chromatography . Combined with chromatography spectral and chromatographic information , by means of principal component analysis in chemometrics and orthogonal projection method to achieve the same kind of traditional Chinese medicine related components under different experimental conditions or different kinds of traditional Chinese medicine chromatographic fingerprints under the same experimental conditions chromatographic peak cluster judgment for objective characterization and evaluation of traditional medicine fingerprint provides a practical , convenient , reliable , and powerful means . Chapter systematically expounded the Chinese herbal Dengzhanhua the chromatographic fingerprints experimental study . Includes choice of extraction solvent , optimization of the chromatographic conditions and methodology investigation , so the chromatographic fingerprint have established systematic characteristic and stability . This will not only provide a theoretical basis for in-depth study of medicinal chemical composition and quality evaluation , and can practice guidance GAP planting and harvesting of herbal medicines . Chapter for the chromatographic fingerprints instrument error and sample error data preprocessing, partial least squares and principal component projection methods such as chromatographic fingerprint pattern recognition of different sources of medicinal herbs , and thus to identify the quality of Chinese herbal medicines authenticity.

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