Dissertation > Medicine, health > Internal Medicine > Systemic disease > Autoimmune diseases > Autoimmune diseases, connective tissue disease > Lupus erythematosus > Systemic lupus erythematosus

Clinical Analysis of Central Nervous System Infection in Systemic Lupus Erythematosus

Author RaoYanZuo
Tutor ZuoXiaoXia
School Central South University
Course Internal Medicine Rheumatology
Keywords Systemic Lupus Erythematosus Intracranial infection Risk factors
CLC R593.241
Type Master's thesis
Year 2007
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Objective: To analyze the clinical features of systemic lupus erythematosus patients with intracranial infection and related risk factors , and provide clinical guidance for its early diagnosis and prompt treatment . : January 2002 to May 2007 all diagnostic hospitalized patients of SLE with intracranial infection were retrospectively analyzed , and select the same period 36 cases of hospitalized patients with SLE do control . Of all patients with SLE disease duration , glucocorticoid usage , cyclophosphamide cumulative dosage of 1 year , disease activity , clinical manifestations and laboratory assistant examination data analysis . Results: SLE patients from January 2002 to May 2007 a ??total of 727 cases , 18 patients with intracranial infection , or 2.48% of the total number of patients , including 10 cases of tuberculous meningitis (55.6%) , cryptococcal meningitis inflammation in 6 cases ( 33.3%) , brain abscess in 2 cases (11.1%) . 11 cases (61.1 %) as the first symptom was fever , 12 cases (66.7%) patients with varying degrees of neck resistance . 1 case ( 5.6% ) were cured , improved in 13 cases (72.2 %) , and 4 patients died (22.2%) . Intracranial infection and control groups in the high-dose hormones impact , one year average daily dosage of glucocorticoids , WBC, lymphocyte count and clinical outcomes , the difference was statistically significant (P <0.05), the time used in hormone 1 year cyclophosphamide cumulative dose , C 3 decline , lupus activity , no statistically significant difference between the two groups . Conclusion: atypical clinical manifestations of systemic lupus erythematosus patients with intracranial infection . The impact of high-dose hormone therapy, the average daily high doses of hormone dosage , WBC , lymphocyte count decreased in SLE ??patients with risk factors for intracranial infection . Repeated CSF examination can improve the rate of diagnosis of intracranial infection .

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