Clinical Analysis of Central Nervous System Infection in Systemic Lupus Erythematosus
|School||Central South University|
|Course||Internal Medicine Rheumatology|
|Keywords||Systemic Lupus Erythematosus Intracranial infection Risk factors|
Objective: To analyze the clinical features of systemic lupus erythematosus patients with intracranial infection and related risk factors , and provide clinical guidance for its early diagnosis and prompt treatment . : January 2002 to May 2007 all diagnostic hospitalized patients of SLE with intracranial infection were retrospectively analyzed , and select the same period 36 cases of hospitalized patients with SLE do control . Of all patients with SLE disease duration , glucocorticoid usage , cyclophosphamide cumulative dosage of 1 year , disease activity , clinical manifestations and laboratory assistant examination data analysis . Results: SLE patients from January 2002 to May 2007 a ??total of 727 cases , 18 patients with intracranial infection , or 2.48% of the total number of patients , including 10 cases of tuberculous meningitis (55.6%) , cryptococcal meningitis inflammation in 6 cases ( 33.3%) , brain abscess in 2 cases (11.1%) . 11 cases (61.1 %) as the first symptom was fever , 12 cases (66.7%) patients with varying degrees of neck resistance . 1 case ( 5.6% ) were cured , improved in 13 cases (72.2 %) , and 4 patients died (22.2%) . Intracranial infection and control groups in the high-dose hormones impact , one year average daily dosage of glucocorticoids , WBC, lymphocyte count and clinical outcomes , the difference was statistically significant (P <0.05), the time used in hormone 1 year cyclophosphamide cumulative dose , C 3 decline , lupus activity , no statistically significant difference between the two groups . Conclusion: atypical clinical manifestations of systemic lupus erythematosus patients with intracranial infection . The impact of high-dose hormone therapy, the average daily high doses of hormone dosage , WBC , lymphocyte count decreased in SLE ??patients with risk factors for intracranial infection . Repeated CSF examination can improve the rate of diagnosis of intracranial infection .