Formylation reaction of guaiacol

The paper as raw material guaiacol , explore the of Reimer - the ladder Cayman reaction and Duff reaction of guaiacol the formylation synthetic vanillin and ortho vanillin method to study the vanillin and ortho isomer ratio of vanillin , effects of reaction time, reaction temperature , total yield and isomer ratio of the amounts of reactants and other factors . The results show that , Reimer - Timothy Mann reaction of vanillin and o- vanillin overall yield can reach 79% , the ratio of the amount of the ortho vanillin and vanillin approximately 0.27 ; Duff reaction gotta the rate can reach 51% , the amount of vanillin ortho vanillin ratio of about 0.4 .