Study of Clinical Application Value of Impulse Oscillometry in Chronic Obstructive Pulmonary Disease
|Course||Department of Respiratory Medicine|
|Keywords||Pulse oscillation method Chronic obstructive pulmonary disease Lung function Respiratory impedance|
[Objective] IOS determination of the value of clinical application of COPD. IOS determination [method] of 154 patients with COPD and 60 healthy controls were measured and pulmonary ventilation and lung capacity was measured parameters were compared, and 30 patients with COPD acute exacerbation and stable pulmonary function measurement and analysis. [Results] COPD group (Ⅰ - Ⅳ grade, a total of 106 cases) Determination of ventilatory function parameters FVC / pre FEV1/pre and FEV1/FVC compared with the control group was significantly lower (P lt; 0.05). IOS determination of parameters Fres Z5/pre R5/pre R20/pre R5-R20/pre significantly higher than the healthy group (P lt; 0.05) Z5/pre R5/pre and R5-R20/pre with disease aggravated elevated of COPD significant differences between groups (P lt; 0.05), X5 significantly lower than the healthy group (P lt; 0.05). The the correlation analysis show Fres, Z5/pre, R5/pre R5-R20/pre with FVC / pre FEV1/pre FEV1/FVC significant negative correlation (P the lt; <.05), the X5 and FVC / pre, FEV1 / pre significant positive correlation (P lt; 0.05). The COPD groups IOS Determination of output graphics was characteristic changes. 48 cases 0 COPD patients pulmonary function test results showed that FVC parameters FVC / pre, FEV1/FVC and the control group FEV1/pre no significant difference (P gt; 0.05) in MEFV curve parameters FEF75/pre, FEF50/pre The control group was significantly decreased, IOS determination the the parameters Fres, Z5/pre, R5/pre and R5-R20/pre compared with the control group increased significantly (P lt; 0.05), X5 compared to the control group significantly decreased (P lt; 0.05), ROC curve analysis showed that the IOS parameters can distinguish between 0 COPD and control groups, moderate diagnostic accuracy. 30 patients with COPD acute exacerbation and stabilization of pulmonary function test results show that more acute exacerbation of ventilatory function parameters FVC, FVC / pre, FEV1, FEV1/pre and FEV1 / FVC stabilization period was significantly increased (P lt; 0.05), and lung volume parameters IC stable period compared with acute exacerbation of a significant increase (P lt; 0.001), ITGV and RV stable period compared with acute exacerbation of significantly decreased (P are lt; 0.01), pulse oscillation lung function (IOS) was measured parameters Fres, Z5, R5, R20 and R5-R20 stable period than acute exacerbation of significantly with decreased (P are lt; 0.05), X5 stable period than acute heavier period significantly with increased (P lt; 0.05), lung volume parameters of the IC, RV and ITGV stable period than acute aggravation of the improvements FVC, improved significantly with related (P are lt; 0.05), the IC and RV stable period of improvement with FEV1 significantly with relevant the the IOS parameters Z5, R5, R5-R20, X5 and Fres stable period improvement in FVC parameters FVC, FEV1 and FEV1/FVC were significantly associated (P lt; 0.05). [Conclusion] IOS determination of good reaction COPD increased airway resistance and peripheral lung tissue disorder characterized by hyperinflation, and abnormalities are more sensitive to small airway function early in patients with COPD, greater clinical value in the diagnosis of COPD. IOS dynamic observation of COPD different course of lung function change measurement can also be used to help understand the COPD different course of lung function to dynamically change the characteristics and mechanisms.