Effect of Hyperbaric Oxygen on Congnitive Dysfunction in Rats with Traumatic Brain Injury
|School||Huazhong University of Science and Technology|
|Keywords||Traumatic brain injury Hyperbaric oxygen Choline acetyltransferase Acknowledge|
Objective: To observe the impact of hyperbaric oxygen on brain trauma induced cognitive sex and the number of positive neurons in the prefrontal cortex and hippocampal choline acetyl transferase (ChAT) , seek effective cognitive behavioral dysfunction after traumatic brain injury treatment . Method : the law of the Feeney free fall impact modeling . 60 Weight 280 ~ 320g healthy adult male SD rats were randomly divided into sham operation group (A group) , traumatic brain injury group (B ) , and traumatic brain injury and hyperbaric oxygen therapy group (C ) , the rats in each group 10 of each model 24d navigation test and spatial search in the water maze experiment . The other 10 of each group simultaneously ChAT - positive cells and the quantitative analysis of the relevant parameters . Number of results : group C rats looking for underwater platform latency less than group B at the same point in time , across space search experiments underwater platform position was significantly higher than that in group B (all P lt ; 0.01) . Group C rat frontal cortex and hippocampus ChAT -positive neurons than the number in group B increased significantly (P lt; 0.01). Conclusion: traumatic brain injury learning ability and memory of the rats were decreased , and hyperbaric oxygen therapy can improve learning and memory disorders of brain injury in rats . Hyperbaric oxygen therapy to inhibit acetylcholine (Ach) degeneration of neurons , so that brain trauma in hippocampus of ChAT - positive fiber hyperplasia , which may be the reason for learning and memory dysfunction of hyperbaric oxygen therapy to improve brain injury in rats .