Dissertation > Medicine, health > Clinical > Therapy > Oxygen therapy,hyperbaric oxygen therapy

Effect of Hyperbaric Oxygen on Congnitive Dysfunction in Rats with Traumatic Brain Injury

Author QinJie
Tutor YouChunJing
School Huazhong University of Science and Technology
Course Rehabilitation Medicine
Keywords Traumatic brain injury Hyperbaric oxygen Choline acetyltransferase Acknowledge
CLC R459.6
Type Master's thesis
Year 2006
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Objective: To observe the impact of hyperbaric oxygen on brain trauma induced cognitive sex and the number of positive neurons in the prefrontal cortex and hippocampal choline acetyl transferase (ChAT) , seek effective cognitive behavioral dysfunction after traumatic brain injury treatment . Method : the law of the Feeney free fall impact modeling . 60 Weight 280 ~ 320g healthy adult male SD rats were randomly divided into sham operation group (A group) , traumatic brain injury group (B ) , and traumatic brain injury and hyperbaric oxygen therapy group (C ) , the rats in each group 10 of each model 24d navigation test and spatial search in the water maze experiment . The other 10 of each group simultaneously ChAT - positive cells and the quantitative analysis of the relevant parameters . Number of results : group C rats looking for underwater platform latency less than group B at the same point in time , across space search experiments underwater platform position was significantly higher than that in group B (all P lt ; 0.01) . Group C rat frontal cortex and hippocampus ChAT -positive neurons than the number in group B increased significantly (P lt; 0.01). Conclusion: traumatic brain injury learning ability and memory of the rats were decreased , and hyperbaric oxygen therapy can improve learning and memory disorders of brain injury in rats . Hyperbaric oxygen therapy to inhibit acetylcholine (Ach) degeneration of neurons , so that brain trauma in hippocampus of ChAT - positive fiber hyperplasia , which may be the reason for learning and memory dysfunction of hyperbaric oxygen therapy to improve brain injury in rats .

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