The Clinical Research for the Effect of Iodine-125 Seeds Implanted in Advanced Bronchial Lung Cancer
|School||Ningxia Medical University|
|Keywords||lung cancer iodine-125 seeds Close radiation therapy|
Objective: The paper in the last two years in clinical use close radiotherapy cases of analysis, the corresponding clinical experience is concluded, for the future clinical work provide the corresponding references and experiences and lessons, and convenient in communication between domestic counterparts.Methods: From November 2008 to December 2010, collect by histopathologic diagnosis of middle-late lung cancer pathological 31 patients, including male 18 cases, female 13 cases, male: female for 1.38:1. Age 40 ~ 75, average age 62.45 years old, median age 64. Histological diagnoses include adenocarcinoma in 10 cases, squamous cell carcinoma in 18 , glandular squamous cell carcinoma in 2 and small cell lung cancer in 1. Reference 7th edition of TNM standard (2010) , stageⅢA 9 cases,ⅢB period in 15 cases,Ⅳ7 cases. KPS score in 40 ~ 70 between. Surgically implanted 125I particles of patients after a half-year follow-up, patients were observed cough, haemoptysis symptom such as mitigation, imaging change, changes in quality of life.Results⑴Intrathoracic permanent of radioactive particles is safe and feasible, all operations are successfully completed, operation monitoring patient vital signs smoothly. 1 in small cell carcinoma patients because of multiple organ metastases, in 2 months abort the therapy, exit treatment didn’t happen serious adverse reactions. This case patients after therapy efficacy evaluation recorded as invalid (NC). The patients were better complete treatment.⑵iodine-125 seeds particle intrathoracic implant treatment middle-late lung cancer short-term curative effect:①Clinical symptoms: 31 cases of cough patients after treatment: treatment group cavity 3 months after complete remission (CR) 3 cases, part catabatic (PR) in 11 cases, efficient of individual heterogeneity. Six months after surgery completely catabatic cases (CR) in 2 cases, part catabatic (PR), 10 cases, laseris 38.71%. 20 cases of haemoptysis patients after treatment: the study group has 20 cases with hemoptysis, 3 months after treatment completely catabatic cases (CR) 3 cases, part catabatic cases, 8 (PR) 55.00% efficiently. 6 months completely catabatic cases (CR) in 2 cases, part catabatic (PR) in 12 cases, efficient 70.00%.②Quality of life: select KPS score evaluation of quality of life of the patients. Lumen radiotherapy over three months KPS ratings on experimental patients, powerfully in 5 cases, effective 9 cases. Six months KPS ratings, experimental patients got 4 cases, effective in 12 cases.③Radiographic: intrathoracic brachytherapy 3 months after radiculopathy have completely catabatic cases in 2 cases, part catabatic 15 cases, stable 7 cases. After the treatment of 6 months radiculopathy have complete remission, 1 case part catabatic 13 cases, stable 9 cases.⑶Tumor pathologically classified and the curative effect relationships: group adenocarcinoma, 10 cases were squamous cell carcinoma in 18 cases, glandular squamous cell carcinoma in 2 cases, small cell lung cancer in one. Intrathoracic brachytherapy for each pathologic types in symptoms improved obviously effect, but each non-significance difference between results, P > 0.05.⑷Experiment this process was not found patients have obvious adverse reactions.Conclusions: (1) the intrathoracic close middle-late radiation treatments for patients with short-term clinical symptoms, the quality of life, and tumor control etc have obvious effect, (2) the pathologic types and intrathoracic close radiation therapy has no obviouscorrelation.