Dissertation > Medicine, health > Chinese Medicine > TCM Internal Medicine > Modern medicine, internal diseases

The Observation of Curative Effect and Influence of Tumor Necrosis Factor-α and Interleukin-10 in Stable Phase of Chronic Obstructive Pulmonary Disease with Deficiency of Both Lung and Spleen by Qiangji Jianli Oral Liquid

Author XiaoHuiZhen
Tutor ZhangWei
School Guangzhou University of Traditional Chinese Medicine
Course Traditional Chinese Medicine
Keywords Chronic obstructive pulmonary disease (COPD) Qiangji Jianli oral solution Lung and spleen deficiency Tumor necrosis factor - α (TNF - α ) Interleukin 10 (IL-10)
CLC R259
Type Master's thesis
Year 2008
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Objective: The efficacy of the deficiency type Qiangji Jianli oral liquid on a stable period Feipi of COPD observed from both clinical and experimental studies of TNF-α and IL-10. Method: 1. Clinical study: 40 patients met the conditions of the patients were randomly divided into a treatment group and a control group. Treatment group with a strong tendon force oral liquid Jiashu the fluorine U.S. treatment of treatment control group Shu fluorine U.S., a course of 3 months, TCM syndrome, changes in lung function, TNF-α and IL-10 concentrations were observed. Experimental study: 20 healthy SD rats were randomly divided into the healthy control group (blank group), COPD model group (model group), Qiangji Jianli oral liquid high-dose group (strong high group) and strong muscle Powerlifting the oral liquid low dose group (strong low group). Intratracheal instillation of lipopolysaccharide, and smoked cigarettes law and the senna diarrhea purgation the rat model of COPD. Observed rats lung tissue pathological, D-xylose excretion rate, TNF-α and IL-10 concentration changes. Results: 1. Clinical studies 1.1 treatment group before and after treatment, the TCM syndromes comparison, have a significant difference (P <0.05 or <0.01); the control group in the sputum, shortness of breath, wheezing, compared with before treatment significant difference (P <0.05), no significant changes in other indexes; compared to the treatment group and the control group after treatment, wheezing and shortness of breath, I indicators improved significantly (P <0.05 or <0.01). Two sets of TCM Therapeutic comparison, the total effective rate in the treatment group improved significantly compared with the control group (89.47% vs 66.7%), P <0.05 1.2 Pulmonary function tests: After treatment, FEV 1 , FVC, FEV 1 in the FEV 1 / FVC, compared with before treatment, improved significantly (P <0.05), but no significant difference in the two groups after treatment, indicating that two Group therapy is very effective in improving lung function. 1.3 two groups of patients after treatment, TNF-α were significantly decreased compared with before treatment, a significant difference (P <0.01), the treatment group compared with the control group decreased more significantly (P <0.05). After treatment, the IL-10 were elevated, a significant difference (P <0.01) compared with before treatment, the treatment group increased more significantly than the control group (P <0.05). Experimental study 2.1 model rats lung tissue pathological changes in line with the characteristics of human COPD, the strong muscle Powerlifting oral solution group emphysema pathology change compared with the model group light. 2.2 rats in each group of D-xylose excretion rate compared with the model group than in the control group was significantly decreased, and between the two there is a significant difference (P <0.05), prompted model group Spleen license mode successfully; Strong low group compared with model group No statistically significant difference (P> 0.05), strong high compared with the model group, D-xylose excretion rate was significantly increased (P <0.05); addition, the strong high-rats D-xylose excretion rate was also significantly high The strong low group (P <0.05), suggest that a high concentration of strong muscle Powerlifting oral solution can effectively improve rat spleen deficiency syndrome climate. 2.3 each group of TNF-α concentration comparison, the model group than the blank group significantly with elevated significance (P <0.05) difference; Strong high group TNF-α concentrations compared with the model group significantly with reducing, there are significant with difference (P <0.01 ), a strong low group and strong high group showed no significant difference (P> 0.05), suggest that a high concentration of strong muscle Powerlifting oral solution inhibited the inflammatory cytokines TNF-α production. 2.4 rats IL-10 concentration compared to a significant reduction in model group than in the control group, the difference was statistically significant (P <0.05); between strong low with the model group showed no significant difference (P> 0.05), The high concentration of IL-10 group than in model group was significantly higher (P <0.01) between the strong low group and strong high group showed no significant difference (P> 0.05), suggest that a high concentration of Qiangji Jianli oral liquid has raised the role of IL-10 levels. Conclusion: 1. Qiangji Jianli oral solution with Shu treatment of fluorine United States, with stable lung and spleen deficiency type COPD patients can improve patients' TCM syndromes significantly reduced TNF-α, and raised the level of IL-10, Th1 and Th2 restore the balance between, but in terms of improvement in lung function, with simple oral Shu fluorine U.S. equivalent efficacy. . Qiangji Jianli oral liquid can improve the general condition of the lung and spleen deficiency type COPD rats and to relieve emphysema pathological morphology, D-xylose excretion rate adjustment of TNF-α and IL-10 levels from cytokine level reveals the mechanism of action of the strong muscle Powerlifting oral treatment of COPD.

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