The strong bone Capsules Clinical observation on the treatment of primary osteoporosis
|School||Hubei College of Traditional Chinese Medicine|
|Course||TCM orthopedics and traumatology|
|Keywords||Qianggu Capsule Primary osteoporosis Clinical observation|
Objective:To evaluate the clinical efficiency and safety of the Qianggu capsule to primary osteoporosis, and to find a safe, convenient and effective way for the treatment of osteoporosis.Methods:Comparative study of traditional Chinese and western medicine, according to Case internalized standard and Case exclusion criteria, from September 2006 to December 2007, 128 patients choosed as primary osteoporosis, in an open, fair, random principle, equally is divided into treatment and control groups, the treatment group sufferer take orally Qianggu capsule as Chinese medicine treatment, the control group patients sufferer takes orally western medicine named Alfacalcidol. All cases were selected to the basic conditions of registration, in accordance with the patient’s clinical symptoms and type Syndrome score, followed by examineing the lumbar spine and hip bone mineral density. All patients were selected to undergo six months of the treatment, there have been rigorous and regular follow-up and review. After the treatment, to evaluate the clinical symptoms score and efficacy again, and review of examineing the lumbar spine and hip bone mineral density, at the same time review the liver and renal function and biochemical indicators, the final statistics with SPSS 13.0 software analysis and comparison of two different treatment to bone pain and other clinical of the efficacy of treatment and to compare two methods to improve the effectiveness of bone mineral density in both the treatment and evaluation of the security.Results:The two groups on the drug to osteoporosis was conspicuous effective, the treatment group, the total efficiency of 87.50%, while the control group, the total efficiency of 68.75%, the total efficiency of the two groups was significant difference (P<0.05 ). To compare the bone pain symptoms scores,the differences before and after the treatment were significantly (P <0.01), the decline in the margin compared of the two groups, there were significant differences (P<0.01). To compare the scores of Chinese medical Syndrome,Two groups of patients before and after treatment integral changes with significant differences (P<0.01), the comparison group there has been a significant difference (P<0.01). The treatment group comparison of Chinese medical type, the type of GanShengkuixu total efficiency is 97.06%, and the type of Pixuxueyu total efficiency is 76.67%, the efficiency of the two type is relatively significant difference (P<0.05). the treatment group of the Clinical type comparison, osteoporosis type I the total efficiency of 86.84%, while the total type II efficiency 88.46%, the two-efficiency comparison, there is no significant difference (P>0.05). The disease degree of the treatment group compared with the efficiency, mild and moderate effects are highly significant difference (P <0.01), moderate and severe illness effects also have significant differences (P<0.05). To compare the improvement of bone mineral density , the treatment group with four parts of bone mineral density significantly increased after the treatment was significant difference (P<0.01) . the control group in four parts of bone mineral density in patients also have different degrees of increase , which compared before and after lumbar spine bone mineral density parts , there was a significant difference (P<0.05), but the femoral neck, wards Triangle and the femur trochanter in all there is no significant difference (P>0.05), the difference between the two groups improvement of bone mineral density Comparison of the highly significant difference (P<0.01). Two groups patients of drug safety after treatment is safe, the treatment group security compared with the control group there was no significant difference (P>0.05). In the observation process, the treatment group of 12 patients after treatment appear mild constipation, and do not serve purge drugs, diet adjustments can ease their own. 15 cases of patients with mild symptoms of xerostomia. 18 patients in the heart rhythm slightly lower, close observation of patients heart rate changes, if necessary, ECG, a 24-hour trip to serious cardiac monitoring, may slightly increase its concentration of calcium, myocardial contraction caused by enhanced, need not special Processing. Control group, 9 patients had anorexia, headache, vomiting symptoms, 6 patients reviewed serum calcium concentration are beyond the normal level, a week after stopping the gradual improvement, not to special handling. All patients have to check liver and kidney function, after treatment had no significant liver and kidney dysfunction. Conclusion:Qianggu Capsule have precise efficacy to primary osteoporosis, can significantly reduce the symptoms of patients with bone pain, but also significantly improved in patients with osteoporosis caused by a series of Chinese medicine syndromes, the results is better to Alfacalcidol. The type of GanShenkuixu deficiency is superior to deficiency of Pixuxueyu type, and the clinical-type I and II effect there is no difference. Compared to the Alfacalcidol , Qianggu capsule could significantly increased bone mineral density in patients with osteoporosis. And the treatment method is safe, convenient and very few adverse reactions occurred, it deserve the promotion and clinical application.