JWSNS joint Pinaverium bromide treatment of diarrhea-predominant irritable bowel syndrome clinical observation
|School||Hubei College of Traditional Chinese Medicine|
|Keywords||Irritable bowel syndrome (IBS) Diarrhea Pinaverium bromide Jia-Wei-Si-Ni-San|
[Objective]Irritable bowel syndrome(IBS)is a variable combination of unexplained,chronic or recurrent gastrointestinal symptoms not explained by structural or biochemical abnormalities.IBS patients may be an extremely difficult group to manage and cost a lot.There are abundant theories and clinical practical experiense to the prevention and cure the syndrome of IBS in the traditional Chinese medicine.It has the characterisic that diagnosis and treament based on overall analysis of syndrome and sign and individual treament.The theory of traditional Chinese medicine is under the guidance of the whole view of Chinese medicine and the negative and positive theory.Manage and achieve the goal of improving patients sydrome and quality of surviving through the dialectical theory.This research aim to observe the clinical curative effect of treating irritable bowel syndrome with Jia-Wei-Si-Ni-San and explore the mechanism from theoretical and clinical aspects.[Method]55 cases with IBS were divided into two groups at random:treatment group (35cases)given decoction Jia-Wei-Si-Ni-San 200 ml bid plus 1 tablet of Pinaverium bromide tid;Control group(20 cases)given 1 tablet of Pinaverium bromide tid.The course of treatment in each group was 4 weeks.After 4 weeks,changes of symptoms and therapeutic effect were observed and analyzed.Then sets up the database and carries on the statistical analysis of the datas.[Results]1 In the treatment group,13 cases have apparent effect,20 cases availability,2 cases nullity;however,in the control group,6 cases have apparent effect,8 cases availability,6 cases nullity.The totally effective rate of treatment group come to 94.29%,While that of control group is 70.00%,and there is a significant difference between the treatment group and control group(P＜0.05).treatment group can improve significantly the symptoms,and the curative effect is better than of control group.2 There were no significant difference on symptom accumulation fraction between two group(P＞0.05)before treatment.Two groups of base-line material before treating have comparability.After 4 weeks treating,there were significant meaning in the symptom accumulation fraction between two group(P＜0.01).3 The single effective rate on symptom improvement showed:In the treatment group,the epigastric fullness,anorexia,all these were superior to the control group.And there was significant meaning in abdominal pain,inertia(P＜0.01)[Conclusion]This research indicate that traditional chinese medicine prescription of IBS could obviously improve the IBS patients clinical symptoms compares favourably with western medicine.Jia-Wei-Si-Ni-San is a safe and effective drug of treating irritable bowel syndrome,and the mechanism might be related to accommodation immunity, disinfection,and prevention canceration etc.