Dissertation > Medicine, health > Chinese Medicine > Chinese medicine practitioners of other disciplines > TCM neurology and psychiatry

Systematic Review of Ginaton for Acute Cerebral Infraction

Author LiJuan
Tutor ZhangJianYu
School Shanxi Medical
Course Integrative Medicine
Keywords Systematic review Ginaton acute cerebral infraction randomized-control-trials Meta-analysis
CLC R277.7
Type Master's thesis
Year 2007
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Objective:To assess the efficiency,safety and clinical economics of Ginaton for acute cerebral infraction.Methods:Randomized controlled trails were applied for systematic review.Search were applied to the following electronic databases:Medline;Cochrane Library;CBMdisc;handsearch was applied in 15 kinds of Journal of Chinese traditional medicine.In addition,we searched the reference lists of papers related to acute cerebral infraction.Two reviewers extracted data independently.The methodological quality of trails was assessed by the Jadad-scale and the RCTs were analysised with RevMan4.2.Results:There were 39 RCTs or CCTs have been identified.22 RCTs with 2488 cases were involved.The methodological quality of all trails was low.The combined results showed that compared with the control group.Ginaton significantly increased clinical efficiency(90.87%VS 76.32%;OR 3.26;95%CI 2.49~4.27;P<0.01);improve neural function defects measured(WMD=-2.8;95%CI -4.77~-0.82;P=0.006);decrease the whole blood high shear viscosity(WMD=-0.05;95%CI -0.96~-0.86;P=0.91);decrease fibrinogen(WMD=-0.71; 95%CI -1.28~-0.15;P=0.01);decrease the whole blood low shear viscosity(WMD=-1.1; 95%CI -4.52~2.33;P=0.53)decrease plasma viscosity ratio(WMD=-0.40;95%CI -0.43~-0.37;P<0.01).Asymmetry showed in "Funnel plot" may be related to publication bias and low quality of methodology.No serious adverse effect has been reported.No economic assessment has been mentioned.Conclusions:We can not draw reliable conclusions from the present data due to the general poor methodological quality and potential publication bias.The efficacy and safety of Ginaton in the treatment of acute cerebral infraction should be evaluated by more rigorously designed, randomized,multiply-center trails.

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