Dissertation
Dissertation > Medicine, health > Neurology and psychiatry > Psychiatry > Cerebral organic mental disorder

The Evidence-based and Empirical Research on the Risk Factors of Mild Cognitive Impairment in the Elderly

Author NieHongWei
Tutor XuYong
School Suzhou University
Course Social Medicine and Health Management
Keywords Mild Cognitive Impairment Evidence-Based analysis Empirical analysis risk factor elderly
CLC R749.1
Type Master's thesis
Year 2011
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Objective:1. From the evidence-based point,the aim of study is to find the epidemiological characteristic and risk factors of mild cognitive impairment in China.2. From the empirical point, the aim of study is to find the epidemiological characteristic and risk factors of mild cognitive impairment in Suzhou.Methods:1. The literature review research method was used.The databases which includes MEDLINE, Springer LINK full text electron periodical, OVID BP & Lippincott Williams & Wilkins (LWW) Total Access Collection, Master Pro Quest abundant paper database , Science Online Chinese journal full text database (CJFD), CQVIP database, WANFANG database were used. The keywords which includes‘Mild Cognitive Impairment’,‘Age-Associated Memory Impairment’,‘Age-Related Cognitive Decline’,‘Age Consistent Memory Decline’,‘risk factors’were used.The limited time was from January,1979 to November,2009.2. The investigative study included two parts which were baseline assessment and case-control study. 4600 old persons from eight communities in Suzhou were investigated by using the scale of Montreal Cognitive Assessment (MocA). The SPSS 17.0 were used to sort out and analyze data. The methods of t test, analysis of variance, chi-square statistics, rank sum test, correlation analysis and regression analysis were used.Results:1.The results,which were based on published papers,showed that the risk factors of mild cognitive impairment were female (OR=1.48, 95% CI:1.18-1.85), senility (OR = 1.89, 95%CI: 1.60-2.22), low education (OR=3.4, 95%CI: 1.42-8.18), hypertension(OR =1.87, 95%CI:1.24-2.82),diabete(sOR=1.47, 95%CI: 1.13-1.92),coronary heart disease (OR=1.75, 95%CI:1.35-2.28) and high cholesterol (OR=1.33, 95%CI:1.03-1.71).2. The investigative results showed that the prevalence of MCI was 9.13% in Suzhou and it was significantly different in different sex(χ2=25.34,P=0.00),age(χ2=48.87,P=0.00), education levels(χ2=644.82,P=0.00), income levels(χ2=97.74,P=0.00), dietary customs(χ2=445.18,P=0.00), personality(χ2=8.94,P=0.01) and participation in community activities(χ2=47.22,P=0.00). The scores of visuospacial and executive functions, naming, attention , language, abstraction, and delayed recall were significantly different except the orientation score in different age of man(P<0.05).But only the scores of visuospatial and executive function attention, language, abstraction, and delayed recall were significantly different in different age of women(P<0.05). The score was higher in men than women in the same age period. It was significantly correlative with scores of visuospatial and executive functions, naming, attention, language, abstraction, delayed recall and orientation (P<0.05). From the case-control result of regression analysis, the factors of income, education levels, marital status and doing housework affected the occurrence of MCI significantly (P<0.05).Conclusion:1、The risk factors of mild cognitive impairment were female, senility,low education, hypertension, diabetes, coronary heart disease and high cholesterol, which was from evidence-based study.2、The empirical research showed that the risk factors of mild cognitive impairment were female, senility,lower education,lower income,bad marriage and less home worker.So it is important to prevent mild cognitive impairment by intervening those people.

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