The Diagnostic Value and Prognosis Assessment of Blood NT Pro-BNP, cTNI and IMA on Myocardial Injury Cased by Acute Parquet Poisoning
|Keywords||Paraquat poisoning Nitrogen-based terminal pro-brain natriuretic peptide Troponin Ⅰ Ischemia Modified Albumin Myocardial injury|
Purpose. Investigate serum N-terminal pro-brain natriuretic peptide (Nterminal pro brain natriuretic pcptide, NT pro-BNP), ischemia-modified albumin (ischemia. Modified albumin IMA) and troponin I (were cardiac troponin I cTNI) level of Herbs the blight (Paraquat, PQ) poisoning patients with the diagnosis of myocardial injury and prognostic value; 2. observe the relationship between serum NT pro-BNP the IMA and cTNI three; Method 1. Grouping: collecting 173 cases of patients with PQ poisoning Depending on the number of oral dose divided into light, medium, heavy, special heavy intoxication group any time arterial blood gas analysis results into hypoxemia group and non-hypoxemia group (in P02 = 60mmHg for the sector), according to the The follow-up results are divided into the group of death and survival group (the follow-up period of six months), and selected 50 cases of healthy persons during the same period as a control group. Specimen collection: in patients on admission to the venous blood serum NT pro-BNP the IMA and cTNI level 1 in the serum NT pro-BNP, IMA, and cTNI level with the increase in the degree of paraquat poisoning and gradually increased . Serum NT pro-of BNP levels moderate poisoning group (180.2 ± 27.9) pg / ml, re degrees poisoning group (378.5, being mandatory ± 74.4) pg / ml, especially heavy degree of poisoning group (445.3 ± 86.5) pg / ml compared with the control group (52.6 ± 7.7 ) pg / ml a significant difference (P LT; 0.01). The mild poisoning group (108.2 ± 18.7) pg / ml compared with the control group no difference (P gt; 0.05); mild poisoning of serum cTNI level group (0.05 ± 0.02) ug / L, and moderate poisoning group (0.10 ± 0.03) ug / L compared with the control group (0.002 ± 0.0) ug / L no obvious difference (P gt; 0.05), heavy degree of poisoning group (0.26 ± 0.09) ug / L, especially heavy degree of poisoning group (0.32 ± 0.12) ug / L compared with the control group There are significant differences (P lt; 0.01), serum IMA level of mild poisoning group (79.7 ± 3.4) U / ml, and moderate poisoning group (96.1 ± 3.8) U / ml, severe poisoning group (99.5 ± 4.8) U / ml, particularly severe poisoning group (117.0 ± 5.8) U / ml than those in the control group (36.5 ± 2.6) U / ml were significantly different (P lt; 0.01). Serum NT pro-BNP cTNI level severe, especially severe poisoning group was significantly higher than the light, in the poisoning group P lt; 0.01, serum IMA level of severe poisoning group with moderate poisoning group were no differences (P gt; 0.05) . Severe, especially heavy poisoning group was significantly higher than that of mild poisoning group (P lt; 0.01). Hypoxemia group compared with the non-hypoxemia group PQ poisoning patients with serum NT pro-BNP, cTNI and IMA levels were significantly higher in the former than the latter significantly higher, the two groups were significantly different, statistically significant, (P lt; 0.01). Death group compared with survival group to PQ poisoning serum NT pro-BNP, cTNI and IMA levels were significantly elevated the former than the latter significantly increased, the two groups have a significant difference was statistically significant (P lt ; 0.01). Serum NT pro-BNP, IMA level changes and serum cTNI level changes linearly positively correlated with serum NT pro-BNP levels changes in serum cTNI level in change r = 0.93 (P lt; 0.05) was highly correlated sex; serum the IMA level change and serum cTNI level changes r = 0.55 (P lt; 0.05) showed moderate correlation. 5. Logisitic regression analysis, prognostic factors affecting the PQ poisoning patients oral dose oral degree of erosion, difficulty breathing, the emergence of the white blood cell count, NT pro-BNP, CK-MB level. Serum NTpro-BNP OR = 5.0, P lt; 0.05,95% CI (1.5-151.3) Conclusion PQ poisoning can cause myocardial injury in patients, serum NT pro-BNP, IMA, cTNI level evaluation PQ poisoning myocardial injury in patients sensitive early indicators; Serum NT pro-BNP, IMA levels the serum cTNI level linear positive correlation in the evaluation of PQ poisoning myocardial injury in patients with synergy. Serum NTpro-BNP, IMA level of PQ poisoning patients prognosis. Therefore, early detection of serum NT pro-BNP, IMA, cTNI diagnosis of of PQ poisoning patients with myocardial injury, poisoning degree of analysis and prognosis has a very important value.