The Study on the Treatment of Middle-aged and Old-aged Dizziness (Vertebrobasilar Insufficiency) with Qing Xuan Ke Li and the Effction on the Function of Blood Vessel
|School||Shandong University of Traditional Chinese Medicine|
|Course||Chinese medical science|
|Keywords||VBI vertigo Collateral Disease Qingxuan particles Vascular function|
Objective: According to the middle-aged vertebrobasilar insufficiency vertigo (hereinafter referred to as VBI vertigo) the characteristics of the disease and the ancient medical research, combined with the instructors use tongluo medications VBI vertigo experience, explore the VBI vertigo Etiology, Pathogenesis and Therapeutic; research VBI vascular changes in biologically active substances, and its effects on vascular function; collateral disease theory of traditional Chinese medicine as a starting point to explore the meridians dharmas contact with the regulation of vascular function by detecting transcranial more Doppler ultrasound (TCD), pial microcirculation, ET (ET), NO (nitric oxide), Ang Ⅱ (Ang Ⅱ), bFGF (basic fibroblast growth factor), PDGF (platelet-derived growth factor ), NF-KB (nuclear factor KB) and other indicators, in order to explore the efficacy mechanism Qingxuan particles. Methods: a clinical study selected 60 patients with VBI vertigo, single-blind randomized into two groups Qingxuan particle test group and control group of 30 cases of Ginkgo biloba, were to be Qingxuan particles and Ginkgo control treatment 1-2 courses. TCM syndromes observed, the efficacy of individual symptoms, brain color Doppler ultrasound, plasma ET, Ang Ⅱ, NO levels and many other indicators. Two experimental studies using high-fat diet vertebral artery compression VBI rat model, divided into high and low dose group Qingxuan particles, Ginkgo control group, model control group. Separate control group. Right temporal lobe at the base of rat dental drill with a drill to open a diameter of about 4 × 4mm cranial window, observing pial microcirculation; using immunohistochemistry, radioimmunoassay, chromogenic substrate method, turbidimetric method and other methods detect vascular wall NF-KB, FGF-2, PDGF-B, plasma ET, Ang Ⅱ, NO, t-PA, PAI, platelet aggregation, blood rheology, blood lipids and other indicators. Results: 1. Clinical research trial group Qingxuan particles TCM syndromes total effective rate was 86.67%; Ginkgo control group, the total effective rate was 66.67%, compared to the two groups were significantly different (P lt; 0.05); simultaneously test group a number of very significant symptom score or a significant reduction (P lt; 0.01 or P lt; 0.05). Experimental group improved cerebral Doppler echocardiography (Vd, Vm, Vs, PI, RI), control of systolic blood pressure, blood rheology (fibrinogen, whole blood viscosity, high shear rate), decreased plasma ET and Ang Ⅱ The role of content was significantly better than the control group (P lt; 0.05); regulate blood lipids, elevated the role of NO levels compared with the control group had no significant difference (P gt; 0.05).