Dissertation > Medicine, health > Surgery > Urology ( urinary and reproductive system diseases) > Of common diseases

Dysregulation of Renal Aquaporins, Sodium Transporters and Acid-base Transporters in Rats with Urinary Tract Obstruction

Author WangGuiXian
Tutor WenJianGuo
School Zhengzhou University
Course Surgery
Keywords BUO AQP NHE3 NBC-1 Na, K-ATPase, H ~-ATPase NBCl NBCnl pendrin
CLC R691
Type PhD thesis
Year 2005
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The important function of the kidneys is to maintain the body's water and salt metabolism and acid-base balance, maintaining the stability of the internal environment, in order to ensure normal life activities. Its mechanism of action and regulation mechanism is more complex, not only neurological factors involved, the more the role of a variety of hormones, and ultimately by changes in tubular membrane channel protein, regulates renal water, electrolyte and acid-base ion reabsorption and secretion, by changing the amount of urine, urine concentration and pH, and maintain a stable balance of body water and salt metabolism and acid-base environment. The aquaporin (Aquaporin, AQP) is a group of transmembrane proteins, distributed in different types of cells in the serosa, referral Road transmembrane transport of liquid. There are at least seven kinds of aquaporin expression in different parts of the nephron to the collecting duct in the mammalian kidney, played an important role on the liquid back to the absorption of the kidney. AQP1: aquaporin first discovered, mainly located on the surface membrane of the nephron proximal tubule and medullary descending artery the fine segment endothelial cells and the basement membrane, the role of the water molecules to penetrate the cell surface membrane and basement membrane in the proximal renal unit weight to absorb moisture, and play a major role in the concentrated urine; AQP2: mainly located in the kidneys connected within the film tube and collecting duct principal cells of the table cells of the smaller capsule is manifold moisture re-absorption of the fundamental substances , AVP regulate water re-absorption in the kidney is mainly through AQP2 work. The experiments show that dehydration and water loading increases could affect AQP2 expression; renal collecting duct principal cells back to absorb moisture concentrated urine, rely on the cell surface membrane AQP2 water into the cells through the cell basement membrane into the surrounding capillaries and circulation, it is necessary, by the side of the basement membrane AQP3 and AQP4 in animal experiments also showed that AQP3, AQP4 on the formation of the final amount and concentration of the urine since a significant role. The most important organs of the kidneys not only play an important role in the regulation of water, but also to regulate sodium excretion in order to maintain the body's sodium balance. The daily renal reabsorption of sodium filtration, is to rely on the result of the different parts of the tubular continuous-action, and each site are distributed special sodium transporter protein or sodium channel responsible sodium reabsorption. Also confirmed by a series of animal experiments, the regulation of these sodium channels plays an important role in a variety of sodium and water balance disorders. Channel NHE3 Na ~ / H ~ exchange is mainly distributed in the the tables membrane of the renal proximal tubule cells, medullary thick ascending limb segment also had a strong performance. The NHE3 role was by the secretion H ~~ to

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