Dissertation > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Myocardial diseases > Myocardial infarction

Effect of Intracoronary Injection of Anisodamine on Coronary No Reflow Phenomenon in York Swines and Acute Myocardial Infarction Patients after Percutanous Coronary Intervention

Author WeiYongYun
Tutor FuXiangHua
School Hebei Medical University
Course Internal Medicine
Keywords Anisodamine Myocardial infarction York swine Percutanous coronary intervention “no reflow”phenomenon Inflammation factors
CLC R542.22
Type PhD thesis
Year 2006
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The obvious pathological and anatomical phenomenon in early stage of acute myocardial infarction(AMI) is the total occlusion of infarction related artery in epicardium. With the gradually deepening research about AMI, recent studies showed that the related arteriole and capillary were so seriously damaged correspondingly once coronary artery occluded that disturbance of distal blood flow in microcirculation in ischemia area might still exist after revascularization, which is defined as no reflow phenomenon(NRP) or slow reflow phenomenon(SRP). Now, reopening the infarction related artery in time with percutanous coronary intervention(PCI) is an effective and satisfactory therapy for most of AMI patients. But NRP exists in 10~30% patients with AMI after PCI that myocardial tissue hasn’t gained complete perfusion, which will surely influence the remodeling process of left ventricle and the incidence of adverse cardiac events. The incidence rate of mortality, reinfarction, malignant arrhythmia and acute or chronic heart failure was many times increased in patients with NRP, which seriously influenced the long term prognosis and life quality. Therefore, how to prevent and treat NRP after PCI has become a great challenge and the study focus of coronary heart disease in every country now.As one of serious and common complications post PCI, NRP may lead to serious disturbance in heart function and hemodynamics immediately after its incidence. The judgement and defination of NRP in clinical is the premise to prevent and treat it. The evaluation of cardiac tissue perfusion according to the TIMI blood flow grading exists obvious limitation while TIMI frame counts(TFCs) and TIMI myocardial perfusion grading(TMPG) could reflect objectively the level of myocardial tissue perfusion, which might be a simple

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