Dissertation
Dissertation > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms

Clinical Application of Gasless Hand-assisted Laparoscopic Techniques in Colon-rectum Cancers and It’s Affection on Immune Function of Human

Author RuanJingDe
Tutor ZhangYangDe
School Central South University
Course Surgery
Keywords gasless hand-assisted laparoscopic surgery Abdominal Wall Lifting Cholecystectomy colorectal resection clinical application immune function acute-phase reaction
CLC R735.3
Type PhD thesis
Year 2006
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Objective: To investigate gasless hand-assisted laparoscopic surgery on the colorectal malignancy and its effection on immune function of human.Materials and Methods: Campare gasless hand-assisted laparoscopic surgery, carbon dioxide pneumoperitoneum laparoscopic surgery and operation on Cholecystectomy, colorectal resections, according to the study of operation time, expense in hospital, number of days, pathologic type, extension of radical cure, and analysis of the blood lymphocytes, immune function of erythrocyte, we could ascertain the application value of gasless hand-assisted laparoscopic surgery.Results: Gasless hand-assisted laparoscopic surgery had no obvious difference with laparoscopic Cholecystectomy on subjective sensation, hemodynamic changes, breathing function, cardiac muscle enzymologic changes.In the process of colorectal cancer resections, gasless hand-assisted laparoscopic surgery had obvious difference with carbon dioxide pneumoperitoneum laparoscopic surgery and operation on operation time, expense in hospital, number of days, pathologic type, extension of radical cure, and analysis of the blood lymphocytes, immune function of erythrocyte because gasless assisted laparoscopic surgery had litter disturb, litter wound, in litter pain, fast function recover, litter complications and hospital stay days.Penetrate into the affections of human immune functions by above three kinds of cure pattern, gasless hand-assisted laparoscopic surgery had obvious difference with the others on blood lymphocytes, immune function of erythrocytes RC3bRR, RICR, RFER, RFIR, IL-6、C-reactive protein(CRP) and so on.Conclusions: The self-made Abdominal Wall Lifting laparoscopic surgery had no obvious difference with carbon dioxide pneumoperitoneum laparoscopic surgery on the fact of operation effection, post-operation hospital stay time.Gastess hand-assisted laparoscopic surgery could avoid of hypercapnia and respiratory acidosis. Abdominal Wall Lifting installation Play an important role on laparoscopic surgery with heart and lung disease and high dangerous patient, had uncompleted advantage with carbon dioxide pneumoperitoneum laparoscopic surgery.Because of the adoption with Gasless hand-assisted technique, we found that the resection effect was promoted great. No matter the resection bowel length or lymph node clearing had obvious dominance, and it had reached the same effect between those two operation groups. There are obvious superiority on operation effect compared with abdomen opening surgery, had no difference on short time follow up, but the long-time curative effect need observed furthermore.Compared with acute-phase reaction and erythrocytic immune function, neutrophilic counts, interleukin-6, natural killer cells, C-reaction protein between gasless hand-assisted laparoscopic surgery and carbon dioxide pneumoperitoneum laparoscopic surgery, we found there were obvious difference on N/L rate, CRP, IL-6, Which provided evidence for evaluate the gasless hand-assisted laparoscopic technique superiority to the traditional surgery, and treatment for clinical immune modulation.

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