Dissertation
Dissertation > Medicine, health > Clinical > Diagnostics > Laboratory diagnosis > Microbiological examination of

Changes of Antibiotics Sensitivity and Their Clinical Features of Emergency Infection Patients from 2005 to 2007 in Beijing

Author QianYuanYu
Tutor MengQingYi
School PLA Postgraduate Medical School
Course Emergency Medicine
Keywords infection bacterium emergency drug sensetivity drug resistance antibiotics coagulation Beijing
CLC R446.5
Type PhD thesis
Year 2008
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Objective: To investigate changes of antibiotics sensitivity of emergency infections in Beijing large hospitals from 2005 to 2007, and study their clinical features including the bacterias distribution, antibiotics sensitivity changes, infection risk factors, infection indicators and blood coagulation changes, et al. Methods: Altogether there were 3536 strains were cultrued in recent three years. All the data such as type of spicemen, bacterium strain identification, antibiotics sensitivity and so on were investigated respectively. Two departments(emergency department and respiratory department) in PLA general hospital were studied with their clinical featrues in 2007. We investigated patients’ hospitalized time, diseases classfication, effect of treatment, strain isolation, antibiotics sensitevity, invasive therapies, high risk factors, APACHE II evaluations, C-reaction protein level and the blood coagulation index and so on. Results: 1. The bacteria distribution and their sensitivity to antibiotics in emergency departments displayed the following charactristics: (1) Sputum, blood and urine were the three main specimen in emergency department. (2) The main bacteria been cultured were P.aeruginosa, S. aureus, E. coli, A. baumannii, and K. pneumoniae, which were similar to the hospital infection. On the contrary, commom bacteria of community infection such as S.pneunomiae and H. influenza were relatively rare. (3) The sensitivity of common antibiotics decreased grately in the recent three years, especially Carbapenems, cephlosporins and quinolones. 2、The emergency infections in general hospital in 2007 had the following characteristics: (1) Lung infection was the first main infection in the two departments. (2) Infection patients hospitalize time in emergency was shorter than respiratory department, and antibiotics number used also was less than respiratory department. (3) The main bacteria were similar in the two departments, but their antibiotics sensitivities were quite different. (4) The severity of infection in emergency department was significant related to factors such as hospitalized time, tracheal intubation and the number of antibiotics used (p≤0.05). (5) Infection bacterium numbers increasing may raise CPR level and promote blood coagulation activity. Conclusion: Emergency infection bacteria in Beijing large hospital mainly showed hospital infection characteristics, but their antibiotics sensitivity were different to hospital infection. In the recent three years, their sensetivity to antibiotics had dropped greatly. The severity of infection in emergency department is greatly related to antibiotics number they used.

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