Spleen heat blood circulation method for the treatment of traumatic gastric mucosal disease
|School||Beijing University of Traditional Chinese Medicine|
|Course||Chinese medical science|
|Keywords||Spleen and heat blood circulation method Liujunzi plus or minus side Gastric mucosal injury Peptic ulcer Molecular mechanisms of|
1.Literature reviewThe diagnosis, etiology, pathogenesis and treatment of peptic ulcer (PU) in both traditional Chinese medicine (TCM) and Western medicine were reviewed. The review showed good clinical effect of traditional Chinese medical treatment, particularly on the quality of ulcer healing.2.Theoretical studyAccording to syndrome differentiation of PU patients, the key therapeutic principle is to invigorate the spleen, clear heat and activate blood. Modified Liujunzi (Six Noble Ingredients) formula is the typical therapy.3. Clinical observationObjective:To observe the therapeutic effect of modified Liujunzi formula on peptic ulcer. Methods: In a randomized control trial, 40 peptic divided into two groups: one group treated with modified Liujunzi formula and omeprazole, and the other group treated with omeprazole and herbal placebo as the control. After four-weeks treatment, the symptoms were assessed clinically and the condition of mucosal recovery was observed endoscopically. Results: Epigastric pain and acid regurgitation was alleviated more obviously in the treated group than that of control group (P<0.05);S2 recovery was more frequently found under endoscopy in the treated group than the control group (P<0.05);no adverse effects were observed during the treatment.Conclusion: Modified Liujunzi formula combined with western medicine could improve the short-term clinical effect of PU.4. Experimental researchObjective:To observe the anti-ulcerative effect of modified Liujunzi formula in rats and investigate its mechanism of protecting the gastric mucosa. Methods: The gastric ulcer model was established by dropping acetic acid on the stomach surface. The rats were randomly divided into different groups: the model group, the herb group and the group of western medicine. All of these rats were treated with different medicines for 10 days. At the end of treatment, the width of mucosal damage, the thickness of regenerated mucous membrane, ulcer area, ulcer index, and 6-keto-PGF1α, NO, NOS, EGF, bFGF and H2S contents in gastric tissue were detected. Results: Ulcer area and ulcer index were significantly reduced in the modified Liujunzi formula group when compared with the model group (P<0.01); the regenerated mucosa in the modified Liujunzi formula group was thicker than that in the model group (P<0.05 or P <0.01). Mucosal contents of 6-keto-PGF1α, NO and NOS in the herb group were higher than those in the model group (P<0.01); mucosal contents of EGF, bFGF and H2S in the modified Liujunzi formula group were fewer significantly than those in the model group (P<0.01). Conclusion: Modified Liujunzi formula could protect the gastric mucosa against acid erosion. It could increase 6-keto-PGF1α, NO and NOS contents and decrease EGF、bFGF and H2S content in gastric mucous of gastric ulcer, which may be one of mechanisms of protecting gastric mucosa.