Study of Preparation Process and Quality Standard of Xingting Granules
|School||Chengdu University of Traditional Chinese Medicine|
|Keywords||Xingting Granule Preparation technics Quality standard Stability|
Xingting granule is composed of Scutellaria baicalensis Georgi, Ligusticum chuanriong Hort and six other herbs. The functions is used in the treatment of asthma due to heat-phlegm obstructing lungs by clinical observation, with the efficacies of removal of heat-phlegm and relieving cough and asthma.The research of extraction technics, preparation technics, quality standard and prelininary stability is the main work.To study the extraction technology and preparation technology the method of orthogonal experiments were used. The best extraction technology and preparation technology are that:use60%of ethanol to extract Ligusticum chuanxiong and Peucedanum praeruptorum3times, first time use7-fold volume of ethanol, last two times use6-fold volume of ethanol, each time last30minutes, after extraction filtering and combining the ethanol solutions; use water to extract the other herbs3times, first time use14-fold volume of water, last two times use12-fold volume of water, each time last90minutes, then filtering and combining the extractive solutions, decompress and reclaim the ethanol, break it up after dry it in vacuum. According the proportion, put dextrin and lactose monohydrate into the drug powder, then spray80%ethanol into the powder evenly and granulating, dry the granule at60℃.By this way, can harvest1000g granule.TLC was used to identify Scutellaria baicalensis, Ligusticum chuanxiong, Peucedanum praeruptorum, Perilla frutescens and Pheretima in the Xingting granule, in the research of the quality standard. HPLC was used to compute the content of baicalin. The baicalin’s content of Xingting granule must more than18mg·g-1, according the study,. Meanwhile, the research about the moisture content, weight deviation, granularity and dissolubility was made in this subject.As long as6months in ordinary temperature, the stability study was made. After the research, Xingting granule was consistent with the standard. Result:The preparation process of Xingting granule is reasonable; the quality is stable.