Research of Cervical Spondylosis Treated by Acupunctuirng on Xuangzhong (GB39) with the Technique of fMRI
|School||Hubei University of Chinese Medicine|
|Course||Acupuncture and Massage|
|Keywords||Acupuncture Xuanzhong fMRI Cervical Spondylosis|
ObjectiveTo explore the mechanisms of acupuncturing xuangzhong (GB39)effects in Cervical Spondylosis patients，we compared the brainactivation on the normal and cervical spondylosis group,and co-nducted dynamic functional connectivity analysis.Methods20healthy volunteers(age20-50years)from Hubei University ofChinese Medicine and the social and20cervical spondylosis pa-tients from acupuncture clinic of the First Hospital of Wuhan,a-ll right-handed, were enrolled by May to December in2012.The treatment of both groups was done at the same time of e-veryday, and acupuncture was performed in right leg via acupointGB39by the same doctor.The needle was inserted perpendicular to the skin’s surface to a depth of approximately0.8-1.0cun.Acupuncture stimulation was administered using stimulation-rest-ing alternating pattern.3.0T HDXT MRI system (USA General Electric Company)was used for this study.fMRI scan use EPI sequence parameters:TR/TE=3000ms/40ms,FA90°,slice thickness5mm,spacing0mm matrix=96×96,s-can time was6min24seconds.Data were post-processed and analyzed by using Statistical P-a rametric Mapping software(SPM8)and the results were obtained byusing xjview8software.For all data,statistical thresholding atsignificance level of p＜0.05and k≥10was initiallyused to determine significant activation for each voxel.Result1.2cases of20normal subjects were detected that the head of the three-dimensional rotation is greater than1.5°or dime-nsionaltranslational greater than1.5mm in the motion correcti-on process,the data were to be discarded.1case of20cervicalspondylosis subjects were detected that the head of the three-dimensional rotation is greater than1.5°or dimensional transl-ational greater than1.5mm in the motion correction process,t-he data are to be discarded.Finally,the data of18cases in nor-mal group,19cases in cervical spondylosis group are qualifie.2.None of Brain regions of both groups in resting state was activated.3.Activated regions in normal group after acupuncturing xua-nzhong: the left sperior temporal gyrus, cingulate gyrus; bila-teral inferior parietal lobule,transverse temporal gyrus,insul-arcortex,inferior frontal gyrus,posterior central gyrus;bilate-ralprecentral gyrus,middle temporal gyrus.4.Activated regions in cervical spondylosis group after acup-uncturing xuanzhong:bilateral cerebellum, superior temporal gy-rus,middle temporal gyrus,inferior parietal lobule,occipitalob-e,posterior central gyrus,inferior frontal gyrus,transverse te-mporal gyrus,bilateral precentral gyrus,insular cortex.5.The same activated regions in both groups:bilateral infer-ior parietal lobule,transverse temporal gyrus,insular cortex,in-ferior frontal gyrus,posterior central gyrus;bilateral precent-ral gyrus,middle temporal gyrus.The mainly different activati-on of both group:cerebellumand occipital lobe.ConclusionThe effects of acupuncture analgesia were probably produced by the interaction of multiple brain structures of functional c-onnectivity rather than through the activation of a single br-ain region.Theactivative regions and its main medical may havesome relevance.Many of same regions of brain which were activa-ted in both groups may be related to the specific activation ofthe therapeutic effects of xuanzhong acupuncture.The specific a-ctivative regions of cervical spondylosis group were cerebell-um and occipital lobe,which may be one of mechanism of treatingcervical spondylosis by xuanzhong acupuncture in our study.