Clinical Research of Simolang Oral Liquid and Compound Glutamine Enteirc Capsules for Treating Diarrhea-predominant Irritable Bowel Syndrome
|School||Hubei University of Chinese Medicine|
|Course||Traditional Chinese Medicine|
|Keywords||Irritable bowel syndrome(IBS) Diarrhea predominant Dispersing stagnated liver-qi and invigorating spleen ProprietaryChinese medicines brain-gut peptide|
Objective:To observe the clinical efficacy of Simotang oral liquidcombined with Compound glutamine enteric capsules in the treatmentof Diarrhea-predominant Irritable Bowel Syndrome belonging toliver depression and spleen deficiency pattern,as well as theclinical effect of these drugs on patients’Serum5-HT and SP.Methods:60patients were randomly divided into two groups,30intreatment goup with1case defluxion,and30in control group withoutdefluxion.All patients were informed the related knowledge about the illness,to be relaxed,as well as to avoid incentives.Besidethat,patients in treatment group were treated with Simotang oralliquid(10ml,po,tid) and Compound glutamine entericcapsules(0.4g,po,tid),while patients in control group were givenTrimebutine Maleate(200mg,po,tid) andMedilac-S(500mg,po,tid).The course of therapy was4weeks.Clinicalsymptom scores,5-hydroxytryptamine(5-HT) and substance P(SP) ofboth groups were evaluated respectively before and aftertreatment.Incentives,recurrence rate and adverse reactions wererecorded.Results:1.The total effective rate and marked effective rate after treating1,2,4weeks of two groups had no significant difference(P＞0.05).The differences of total symptom scores and cure rate aftertreating1,2weeks between two groups were nonsignificant(P＞0.05).4weeks later,the total symptom scores of treatment groupwere apparently lower than that of control group,and the cure rate was41.4%,which was apparently higher than that of controlgroup(16.7%).The difference between the two groups was significant(P＜0.05).2.One week later,the comprehensive effect of treatment group waslower than that of control group,while,after that,the growth ofclinical effect was faster.Finally,the clinical effect oftreatment group was superior to control group after treating2,4weeks.3.One week later,the score of each symptom,total effective rate andcure rate of main symptom of two groups had no significantdifference(P＞0.05).2weeks later,in treatment group,the decreaseof abdominal distension scores as well as cure rate were apparentlysuperior to control group.The difference between the two groups wassignificant(P＜0.05).The changes and cure rates of abdominaldistension as well as defecation urgency in treatment group wereapparently superior to control group at4th week.The differencebetween the two groups was significant too(P＜0.05).While the difference of comprehensive effect of other symptoms at2,4th weekbetween two groups was nonsignificant(P＞0.05).4.The5-HT,SP value of patients in the two groups had significantdecrease after treatment(P＜0.05).Decline of5-HT of treatmentgroup was more remarkable than that of control group,there existedsignificant difference between the two groups(P＜0.05).While thedifference of decline in SP between two groups was nonsignificant(P＞0.05).5.The recurrence rate at4weeks after drug withdrawal of treatmentgroup and control group was10.3%and32.1%respectively.Thedifference between the two groups was significant(P＜0.05).6.The main incentives of the illness were injured emotion anddietetic irrationality,others incentives such as overwork,climatefactors,even unknown causes were less common.The recurrence rateof patients with unknown incentives was50%(5/10),higher than thatof patients with definite incentives(14.3%,7/49).Among the mostrecurrent patients with definite incentives(6/7)，the incentive of recurrence was the same as pretherapy.7.Obvious adverse reactions were not found in the two groups.Conclusion:Simotang oral liquid combined with Compound glutamineenteric capsules have evident therapeutic effect onDiarrhea-predominant Irritable Bowel Syndrome belonging to liverdepression and spleen deficiency pattern.The total effective rateresemble the control group,while cure rate is prominent,especiallygood at releasing abdominal distension and defecationurgency.Although the treatment group takes effects slower, it workslonger,and with lesser recurrence,as well as good safety.Themechanism may be related to the decrease of5-HT,SP.