Erzhi Tiangui Granules on the Influence of Endometrial CTmRNA Expression
|School||Shandong University of Traditional Chinese Medicine|
|Keywords||Nourish kidney endometrial receptivity CTmRNA Erzhi TianguiGranules|
Objective: To observe Erzhi TianGui granules (ETG)to IVF ready to cycle theinfluence of endometrial CTmRNA expression, and explore the mechanism of TranditionalChinese Medcine(TCM)in improving controlled ovarian hyperstimulation(COH)endometrial receptivity.Methods:70infertile women undergoing In vitro Fertilization and EmbryoTransfer(IVF-ET)were randomly divided into two groups. treatment group, pretreatmentedwith ETG of1cycles and after unite with gonadotropin (Gn)(35cases)，and control group，pretreatmented with Liuwei dihuang granules of1cycles and then unite with Gn (35cases)，In the pretreatmented period of about21days(Namely the implantation window),through patients with the informed consent to suck up a little of endometrial tissue,then inEppendof tube for liquid nitrogen cans of freeze-stored,use RT-PCR, to testing CTmRNAtemporal expression;then to evaluate the syndrome points of TCM，thickness and type andvolume of endometrium、 pulsatility index (PI)and resistent index (RI) of uterusartery,Serum hormone levels，Of follicular situation on the day of HCG injection wereobserved.Moreover,clinical pregnancy rates were compared between these two groups.Results:(1)There were statistical significance before and after the treatment in thesyndrome points of Kidney-deficiency, But the treatment group than in the control groupcurative effect is distinct（P<0.05）;（2）The follicular score、endometrial thickness、endometrial volume on HCG day were significantly higher than those in the control group（P<0.05）,endometrial type A and uterine artery blood flow parameter(PI、RI) had beengreatly improved,the difference between the two groups was significant（P<0.05）;(3) Serum levels of estradiol in treatment group on the day of HCG injection was slight higherthan the control group, But the difference was not statistically significant（P>0.05）,whileserum luteinzing hormone(LH) and progestogen(P)levels in the two groups were similar（P>0.05）;(4) Clinical pregnancy rates were also significantly higher than those in thecontrol group, there was significant difference（P<0.05）.(5) Two groups of endometrialCTmRNA in all have expressed, But the treatment groups expressed obvious enhancementthan the control group,there was significant difference（P<0.05）.Conclusion: Traditional Chinese medicine of Erzhi TianGui granules through theimprovement of endometrial receptive, and improve the clinical pregnancy rate, itscurative effect mechanism and improve the endometrial may CTmRNA expression inrelevant.