Dissertation
Dissertation > Medicine, health > Internal Medicine > Infectious disease > Viral infections > Acquired Immune Deficiency Syndrome ( AIDS AIDS)

Correlation Study of Mucocutaneous Diseases and Immune Status in HIV/AIDS Patients

Author YangShiZuo
Tutor LiYuYe
School
Course Dermatology and Venereology
Keywords HIV AIDS mucocutaneous diseases
CLC R512.91
Type Master's thesis
Year 2013
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Objective:To learn the characterization of the mucocutaneous diseases of HIV/AIDS patients in Yunnan Province and evaluate the value of AIDS-related mucocutaneous deseases in the early diagnosis of HIV/AIDS and its immune status, which provide the basis and clues for AIDS prevention.Methods:The objects of this study were the HIV/AIDS inpatients in the First Affiliated Hospital of Kunming Medical University, the No.3People’s hospital of Kunming, and AIDS Care Centre of Yunnan Infectious Disease Hospital during the period from September2007to June2012. Most of the mucocutaneous lesions could be diagnosed accorded to these processes:collecting the clinical background of patients; inquiring the prevalence situations of the associated mucocutaneous diseases, doing the specialist examination on the condition of exposure including the mucocutaneous of oral cavity and nasal cavity and so on; collecting the related image information; the test of CD4+T cell count and anti-TP and others. In terms of some atypical cases, the histopathology of lesion and the culture of fungi was beneficial to the diagnosis, as well as, some tests such as gonococci culture and detecting chlamydia trachomatis should be did for the patients which had Urethral abnormal discharge. The data were input to the Excel database and analysised for the correlation among clinical epidemiological data, mucocutaneous diseases and immune status by SPSS19.0statistical software.Results:Of the508HIV/AIDS patients included,86.0%(437) presented mucocutaneous diseases whose average CD4+T cell counts(327.8cells/μL) were lower than the patients with no the mucocutaneous lesions. The CD4+T cell counts (114.1cells/μL)of the patients complicated mucocutaneous lesions(≥3) were significantly lower than both those(192.1cells/μL) of complications(≥2) and those(213.0cells/μL) of complications(≥1). As the CD4+T cell counts decreased, the prevalence of mucocutaneous diseases went up, and93.7%of the patients whose CD4+T cell counts<200cells/μL complicated with mucocutaneous diseases. The mucocutaneous diseases of HIV/AIDS patients included the infectious, inflammatory, neoplastic diseases such as herpes zoster, oral candidiasis, superficial mycosis, herpes simplex.36.4%of HIV/AIDS patients had suffered from herpes zoster, compared with the patients suffered from that≤1time, the CD4+T cell counts(114cell/μL) were lower than those of the patients sufferd from that≥2times. Some diseases such as herpes zoster,oral candidiasis.condyloma acuminatum,genital herpes,oral leukoplakia, penicilliosis marneffei,cryptococcosis,HIV-PEE represented frequently for the patients whose CD+4T cell counts<200cells/μL, but the eczema was suffered for those(≥200cells/μL). Some disorders such as OHL, Kaposi Sarcoma, penicilliosis marneffei played an important role in the diagnosis. The diseases such as recurrent herpes zoster, facial infectious molluscum, Cryptococcosis, giant condyloma acuminatum were vital to the diagnosis as well. The common clinical characteristices of other mucocutaneous diseases included wide lesion area, atypical, severe, rapid development. HAART could decline the prevalence of herpes zoster, oral candidiasis, Condyloma Acuminatum, genital herpes, oral leukoplakia, penicilliosis marneffei, Cryptococcosis.Conclusion:The mucocutaneous diseases were common in HIV/AIDS patients. There was a negative correlation between CD+4T cell counts and the prevalence and disease category. The patients who suffered from three mucocutaneous diseases at least shoud be considered to the possibility of HIV/AIDS. HAART were able to decrease the prevalence of the mucocutaneous disease in HIV/.AIDS patients, and several mucocutaneous diseases were the sign of exacerbation for HIV/AIDS patients. OHL, Kaposi Sarcoma, penicilliosis marneffei played an important role in the diagnosis. The diseases such as recurrent herpes zoster, facial infectious molluscum, Cryptococcosis, giant condyloma acuminatum were vital to the diagnosis as well. The common clinical characteristices of other mucocutaneous diseases included wide lesion area, atypical, severe, rapid development. The HIV/AIDS patients suffered from herpes zoster, oral candidiasis, Condyloma Acuminatum, genital herpes, oral leukoplakia, penicilliosis marneffei, Cryptococcosis, HIV-PEE warned that CD+4T cell counts may be<200cells/μL.

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