Dissertation > Medicine, health > Surgery > Surgical operation > Anesthesiology

Effects of Sufentanil Combined with Dexmedetomidine on Postoperative Analgesia in Children Undergoing Tonsillectomy

Author YangLiJun
Tutor ChenYanQing
School Fujian Medical
Course Anesthesiology
Keywords Dexmedetomidine Sufentanil Postoperative analgesia Tonsillectomy
CLC R614
Type Master's thesis
Year 2013
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Objective: To observe the effect of sufentanil combined withdexmedetomidine on Patient-controlled analgesia in children undergoingtonsillectomy.Methods: Eighty children with ASA physical status I or II undergoing elective tonsillectomy were randomly divided into four groups(S,SD1,SD2,SD3) with20each: group S received sufentanil0.04ug.kg-1.h-1, groupSD1received sufentanil0.03ug.kg-1.h-1+dexmedetomidine0.03ug.kg-1.h-1, groupSD2received sufentanil0.03ug.kg-1.h-1+dexmedetomidine0.04ug.kg-1.h-1, groupSD2received sufentanil0.03ug.kg-1.h-1+dexmedetomidine0.05ug.kg-1.h-1. ThePatient-Controlled Analgesia pump was set in all children as follow: a initial dose0ml,continuous perfusion rate2ml/h, single bolus2ml, lockout time15min, totalvolume100ml. Faces pain scale(FPS) and Ramsay sedation scale were recorded at30min,1h,2h,4h,12h,24h and48h postoperatively. The number ofpatient-controlled press of the pump and the incidence of side effects wererecorded.Results: FPS of the four groups unless group SD1at all the time points wereless than4. Compared with group S, group SD1had higher FPS scores at2h,4hpostoperatively (p<0.05),group SD2,SD3had lower FPS scores at4h,12hpostoperatively(p<0.05). Compared with group S, group SD3had higher Ramsayscores at2h,4h postoperatively(p<0.05).The number of self-controlled press of thepump in group SD1was markedly more than other groups (p<0.05). Theincidence of nausea and vomiting in group S was higher than groups SD2,SD3(p<0.05). Conclusion: Dexmedetomidine can reduce postoperative consumption ofsufentanil in Children undergoing tonsillectomy, decrease the incidence of nausea andvomiting and sustain an stable hemodynamics. The recommended dose ofdexmedetomidine is0.04ug.kg-1.h-1.

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