Effects of Different Doses of Parecoxib Sodium on the Sufentanil Amount of Patients Undergoing General Anesthesia
|Keywords||parecoxib sodium sufentanil Narcotrend index|
PurposeThis study through intraoperative application of different doses of parecoxib sodium anesthesia in patients undergoing sufentanil infusion rate, and to investigate the injection of parecoxib sodium by reducing the stimulation of pain on the body reduce intraoperative sufentanil infusion rate and dosage and intraoperative or postoperative complications, and provide a basis for the rational use of drugs of clinical anesthesia.MethodsSelected60cases of gynecologic oncology underwent extensive hysterectomy with oophorectomy and pelvic lymph node dissection, the ASA classification Ⅰ-Ⅱ class, age18-65years old, were randomly divided into four groups (n=15cases):IV0.9%sodium chloride injection group (Group Ⅰ), intravenous parecoxib sodium10mg group (group Ⅱ), intravenous Parry celecoxib sodium20mg group (Ⅲ group), intravenous parecoxib sodium40mg group (Ⅳ group). Patients were fasting12hours and deprivation4hours water on routine preoperative,30minutes of preoperative intramuscular injection of penehyclidine hydrochloride1mg. After the patient into the operating room, the open venous access, artery puncture catheter under local anesthesia, continuous monitoring, MAP, HR, SPO2, ECG, and other using the Marquette egale-3000multi-function monitor. Anesthesia was induced with midazolam0.1mg/kg, sufentanil0.4μg/kg, propofol1.0mg/kg, sulfonic acid cis atracurium0.15mg/kg, general anesthesia, after tracheal intubation received anesthesia machine of mechanical ventilation, tidal volume the8ml/kg, frequency12times/min. Micro pump infusion of propofol (6mg/kg·h), sufentanil and sulfonic acid cis atracurium (0.15mg/kg·h),to maintain the anesthesia.At the beginning of surgery to maintain the Narcotrend index in at least20minutes after the D2stage. Ⅰ group was injected with0.9%sodium chloride5ml injection, Ⅱ, Ⅲ Ⅳ group, respectively, with0.9%sodium chloride5ml injection diluted parecoxib sodium lOmg,20mg,40mg. selected another administration of intravenous access, and adjusted the infusion rate of sufentanil, to keep Narcotrend index in the D2stage, recorded MAP, HR, SPO2, and micro pump speed of infusion of sufentanil.at TO (immediately before administration), T1(after administration of5minutes), T2(30minutes) after administration, patients with T3(two hours) after administrationStatistical analysismeasurement data were expressed as mean±standard deviation (x±s), application SPSS13.0statistical package analysis of data, using time series analysis of variance to compare the data between or among the two groups, q test was used in pairwise comparisons; using Chi-square test to analysis the counting data, P<0.05was considered statistically significant.ResultsThe heart rate, mean arterial blood pressure and oxygen saturation change in four groups, p>0.05, the difference was not statistically significant; comparison of the intraoperative sufentanil infusion rate in four groups:compared with Ⅰ, Ⅱ, Ⅲ group, T2, T3, time difference was statistically significant in IV (p<0.05),there were no statistically significant between Ⅰ, Ⅱ, Ⅲ group (p>0.05). the T2T3, respectively compared with T0, T1time in group IV, there was a statistically significant difference (p<0.05), compared with T2and T3time,the T0and T1time had no statistically significant differences (p>0.05).ConclusionThe intravenous parecoxib sodium40mg can significantly reduce the rate of sufentanil infusion undergoing general anesthesia in patients.