Dissertation > Medicine, health > Neurology and psychiatry > Neurology > Brain diseases > Epilepsy


Author GuoJing
Tutor LiuXinJie
School Shandong University
Course Pediatrics
Keywords epilepsy teenage quality of life scale
CLC R742.1
Type Master's thesis
Year 2013
Downloads 31
Quotes 0
Download Dissertation

Objectives:Through evaluationthe quality of lifcteenagers epilepsy children and their parents to comparison and analysis of quality of life in children on their own subjective feelings and objective evaluation of the quality of life of children with their parents.Investigation of the children with epilepsy drugadverse reactions and psychological state of parents of childrento study the influencing factors of quality of life of children with epilepsy. In order to explore the effective measures to improve the quality of life of young children with epilepsy.Methods:1. The researchobjectsTake the non random sampling method the46cases, that were selected in the center of Qilu Hospital of Shandong University medical diagnosis and treatment of children with epilepsy from2010December to2011November2The research toolsAll data was collected by the cross-sectional study, by thequality of life in epilepsv inventory for adolescents(QOLIE AD48),which was developed by the United States Yale University School of medicine’s Cramer、by the child epilepsy questionnaire--parental form, that was designedby Australia’s Sabaz and colleagues in2000, bythe Professor Hague developed Hague Side Effects Scale in1996, by Zung K in the1965establishment of theSelf-Rating Depression Scale、Zung K in the1971establishment of theSelf-Rating Anxiety Scale.3.statistical treatmentAdopt SPSS13.5software input all data analysis, the cases of patients’ demographic data, quantitative data and background information, continuous data to mean± standard deviation, said the study variables between epileptic children with quality of life between groups using single factor analysis of variance, analysis of the survey object general data of epilepsy in children with quality of life; Comparison between groups using t test; Scale of anxiety depression according to the result of normality test, t test, analysis of the survey object’s influence on the quality of life in children with anxiety depression; Between influence factors and epilepsy patients quality of life score using the partial correlation coefficient method and multivariate stepwise regression analysis, analysis of the influence degree of the quality of life in children with epilepsy.Results:1.The quality of life in epilepsv inventory for adolescents score from low to high order of social support, epilepsy attitude, physical function, school performance, health concept, shame, memory/attention, effect of epilepsy. Children with epilepsy social support score the lowest, followed by physical function and school performance. Compared with normal healthy children, memory/concentration, body function and health concept three factors control was statistically significant (P<0.05), memory/concentration and physical function of two factors of statistical significant differences (P0.011), social support and school performance has no statistical significance (P>0.05).The quality of life in childhood epilepsy questionnaire of physical function score was (39.67±7.34); cognitive ability scores (88.91±30.73); emotional health score was (80.34±17.24), the control factors and depression scores the lowest score (36.58; social function±8); behavior function score was (59.49±13.06) points.2.All of the patients were taking medication, single drug patients accounted for36.96%, the reaction of adverse drug reaction scale score was27.11±7.43; the score of side effects and measurement of the related to20.67±5.45, the adverse reaction of high frequency are diarrhea, trembling, trembling, walking instability, dizziness, vertigo; long term medication adverse reaction scores mean was6.43±2.60, higher frequency of occurrence is unresponsive and abnormal behavior. 3.According to Chinese norm, SDS score≥41were the parents of children with depression in24cases (52.17%); SAS score≥40detected with anxiety in parents of children with39cases (84.78%)4.In general demographic data, disease and family situation and other factors on the quality of life in children with epilepsy compared, results showed different learning achievement, intelligence and family income of children, the AD-48score was statistically significant (P<0.05).5.Single factor analysis of the quality of life in epilepsy correlation factor No correlation between age, gender, learning and the quality of life of the patients, while positive correlation with their IQ (R=0.330, P<0.05). Age of onset, type of seizure and seizure frequency, duration, and the quality of life in epilepsy has no significant correlation, but has significantly negative correlation with antiepileptic drugs (AEDs) adverse reaction (R-0.495, P<0.01). The family income (R=0.319, P<0.05) and parental awareness of the disease (Rf值0.031, P<0.05) is related to the quality of life in epilepsy. Parents of children with anxiety (R-0.366, P<0.05), depression (R-0.358, P<0.05) with the quality of lifein epilepsy has significantly negative correlation.6. On the influence factors of quality of life in children with epilepsy were analyzed by multiple stepwise regression analysis, the degree of influence are side-effect score, anxiety, depression and IQ。Conclusion:1.The quality of life in epilepsv inventory for adolescents is significantly lower than the normal healthy children, especially in the memory/concentration, body function and health concept of three factors.2.Teenagers epilepsy patients quality of life questionnaire (QOLIE-AD a48) quality of life questionnaire (QOLICE) parents and children epilepsy, according to the survey are children scored lowest social support and social function, followed by the body, school performance and behavior. The quality of life of the patients of subjective evaluation and objective evaluation parents are basic consistent.3.The quality of life of children with epilepsy antiepileptic drug adverse reactions, and epilepsy in children with parental anxiety, depression as a significant negative correlation, and IQ of children, family economic income and parents’ awareness of the disease into significant positive correlation. Antiepileptic drug adverse reaction of them results in the decrease of epilepsy in children with quality of life is the most important influence factors, the second is of parents, children with epilepsy, anxiety, depression and other adverse psychological feelings.4.Monotherapy, select the minimum dose of medication, rational drugto reduce the side effects of antiepileptic drugs is an important target。This plays an important role to improve the quality of life in epilepsy。5.In the drug treatment of epilepsy patients at the same time, pay attention to the patients and parents with mental state timely psychological counseling and actively carry out health education, in order to facilitate the psychological adjustment and improve the quality of this patients。

Related Dissertations
More Dissertations