Study on the Related Factors in Peritumoral Brain Edema of Meningiomas and its Clinical Significance
|School||Huazhong University of Science and Technology|
|Keywords||Meningioma Peritumoral edema Magnetic resonance imaging Spiral CT angiography|
Objective: The study aims to probe into the radiological, pathologicalfactors and intraoperative findings influencing the development of PTBE. Methods:A total of107patients with intracranial meningiomas were studied. Numbers of theedema index (EI=(Vedema+Vtumor)/Vtumor)were used as the extent of PTBE, whichwere obtained from the size of the meningiomas and the associated PTBE on contrastenhancement and T2-weighted(or FLAIR)images of MRI. The relationship between EIand some factors was evaluated, which may play a role in the development of PTBE.The factors included tumor location, size, pathological type, arachnoid layer betweentumor and brain, pial blood supply and compression or stasis of draining veins, whichwere recorded according to intraoperative findings. Pial blood supply of meningiomasevaluated by Spiral CT angiography of31patients. Results: Tumor location,arachnoid layer between tumorand brain, pial blood supply and compression or stasisof draining vein were positively correlated with the incidence of peritumoral edema.An increasing tumor size was associated with an increasing PTBE incidence in thevolume less than60cm3, but tumor pathological type was not related with theincidence of peritumoral edema. Furthermore, tumor location, size, pathological type,pial blood supply and arachnoid layer between tumor and brain were unrelated withthe edema index. However disappearance of arachnoid layer between tumor and brainwere significant correlated with increased edema index. Conclusion: Disappearanceof the arachnoid layer between tumor and brain was significant correlated with the incidence of peritumoral edema and the severity of brain edema. Occurrence ofperitumoral edema was related with tumor location, size, pial blood supply andcompression or stasis of draining vein.