Association Study among Schizophrenia and Cognitive Function and GAD1Gene Polymorphism
|Course||Psychiatry and Mental Health|
|Keywords||Schizophrenia GAD1gene Polymorphism Cognitive function|
Objective To investigate the relationship between GAD1gene SNPrs11542313polymorphism and schizophrenia in Chinese Han population of Kunming District, and its possible impact on cogni tive function of the schizophrenics. Methods The Polymerase Chain Reaction-Restriction Fragment Length Polymorphisms technique(PCR-RELP) was used to detect the genotypes of GADl gene SNPrs11542313in74patient with schizophrenia,78their first-degree relatives and59healthy individuals intelligence, memory and executive function were tested with Wechsler Aldult Inteligence(WAIS), Wechsler Wechsler Memory Scale(WMS)and Wisconsin Card Test(WCST) respectively. The clinical symptoms of patients were measured with the Positive and Negative Syndrome Scale(PANSS). Results Regarding to GAD1gene SNPrs11542313genotypes and allele frequencies, sign if i cant difference was not found among schizophrenic patients, their first-degree relatives and healthy individual s (P>0.05). Compari sons of cognitive function among every group:There were significant di (Terences in arithmatic, digital symbol, block pattern, long-term memory among every group(P<0.05), healthy individuals performs better than patients and/or their first-degree relatives; there were not significant differences in cognitive founction among every genetype patients. Conclusions SNPrs11542313polymorphism of GAD1gene wasn’t associated with schizophrenia and cognitive function of schizophrenic patients; Patients with schizophrenia have global neurocognitive deficits. First-degree relatives also have deficits in some neurocognitive domains with a moderate degree between patients and normal controls.