Dissertation
Dissertation > Medicine, health > Oncology > General issues > Tumor Therapy

Compare with the Cardiotoxicity of Anthracyclines: Adriamycin and Epirubicin

Author WangYinQian
Tutor ZhangXiangYang
School Xinjiang Medical University
Course Internal Medicine
Keywords Adriamycin Epirybicin Chemotherapy Cardiotoxicity
CLC R730.5
Type Master's thesis
Year 2013
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Objective:The use of anthracyclines by observation (adriamycin, epirubicin) drugsfor the changes in the level of electrocardiogram(ECG)and cardial enzymes before andafter chemotherapy in patients with cancer of the main adjuvant chemotherapy.Methods:From January2006to January2011received anthracycline ECG, myocardialenzymes before and after chemotherapy data were analyzed in the first affiliated hospitalof Xinjiang Medical University and diagnosed with cancer patients. Results:In320cases with adriamycin or epirubicin chemotherapy of tumor patients, the abnormal rate ofECG was31.9%, when adriamycin accumulation amount of<200mg/m2,200~350mg/m2,350~500mg/m2,>500mg/m2the abnormal rate of ECG were15.7%,30.2%,47.7%,64.0%; when epirubicin accumulation amount of<200mg/m2,200~350mg/m2,350~500mg/m2,>500mg/m2the abnormal rate of ECG were13.3%,18.5%,32.1%,58.3%. In order to adriamycin and epirubicin as the main auxiliary chemotherapy ECGwere compared, there was no statistical significance(P>0.05), and make a study ofbreast cancer and non Hodgkin’s lymphoma, abnormal rate of breast cancer with TAchemotherapy before and after the emergence of ECG was40%, TE appeared abnormalrate of ECG was20%, with statistical significance(P<0.05). The abnormal rate of nonHodgkin’s lymphoma by CHOP regimen chemotherapy before and after the emergence ofECG was51.4%, use the CEOP schemes the abnormal rate of ECG up to30.8%, Beforeand after chemotherapy in patients with myocardial enzyme, there was statisticalsignificance(P<0.05). Conclusions:There were cardiac toxicity of adriamycin orepirubicin, while the adriamycin’s cardiotoxicitier than epirubicin. The cardiac toxicityincreased with the accumulation of drugs.

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