Dissertation
Dissertation > Medicine, health > Oncology > Gastrointestinal Cancer > Gastric neoplasms

The Function of Cd44V6、VEGF-C and TGF-β1in the Gastric Carcinoma with Peritoneal Metastasis

Author HanChao
Tutor ShiLianGang
School Dalian Medical University
Course Surgery
Keywords gastric carcinoma peritoneal metastasis CD44V6VEGF-C TGF-β1
CLC R735.2
Type Master's thesis
Year 2012
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Objective:The purpose of this study was to investigate the expression of CD44V6、VEGF-C and TGF-β1in gastric cancer with peritoneal metastasis may help us comprehend its metastasis. It is significant in monitoring carcinogenesis and in offering reasonable therapeutic regimen.Method:S-P immunohistochemical stain was employed to detect the expression of CD44V6、VEGF-C and TGF-β1gene in39cases of gastritis tissue and71cases of gastric cancers in which28cases with peritoneal metastasis and43cases without peritoneal metastasis. The correlations of the expression of CD44V6、VEGF-C and TGF-β1were analyzed by statistics. All statistical analyses were carried out with SPSS11.5, P<0.05was considered significant.Result:1.The positive expression rate of CD44v6in gastric cancer with peritoneal metastasis was89.28%, while it was7.69%and53.49%respectively in gastric cancers without peritoneal metastasis and gastric tissue. The positive rate of CD44v6was significantly higher in gastric cancer with peritoneal metastasis compared with that in gastric cancers without peritoneal and gastric tissue (P<0.01)2. The positive expression rate of VEGF-C in gastric cancer with peritoneal metastasis was89.28%, while it was12.82%and60.47%respectively in gastric cancers without peritoneal metastasis and gastric tissue. The positive rate of VEGF-C was significantly higher in gastric cancer with peritoneal metastasis compared with that in gastric cancers without peritoneal and gastric tissue (P<0.01)3. The positive expression rate of TGF-β1in gastric cancer with peritoneal metastasis was92.85%, while it was15.38%and44.19%respectively in gastric cancers without peritoneal metastasis and gastric tissue. The positive rate of TGF-β1was significantly higher in gastric cancer with peritoneal metastasis compared with that in gastric cancers without peritoneal and gastric tissue (P<0.01)4. The expression intensity of CD44V6, VEGF-C and TGF-β1between any pair of them in gastric cancer with peritoneal metastasis are positively correlated. Correlation analysis between CD44V6with VEGF-C concluded that rs=0.605and be significant (P<0.05) in gastric cancer with peritoneal metastasis. Correlation analysis between CD44V6with TGF-β1concluded that rs=0.551and be significant (P<0.05) in gastric cancer with peritoneal metastasis. Correlation analysis between VEGF-C with TGF-β1concluded that rs=0.448and be significant (P<0.05) in gastric cancer with peritoneal metastasis. The expression of CD44V6, VEGF-C and TGF-β1in gastric cancer with peritoneal metastasis is positively correlated.Conclusion:The overexpressions of CD44v6, VEGF-C and TGF-β1have correlation with peritoneal metastasis tumors and They have a synergistic effect to promote tumor peritoneal metastasis. Detection of expression in gastric carcinoma is helpful to provide new ideas for inhibition of its peritoneal metastasis.

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