Intervention of Anisodamine on Resuscitation of Cardiac Arrest Swine
|School||Zunyi Medical College,|
|Keywords||anisodmine epinephrine cardiac arrest coronary perfusion perssure cardiopulmonary rususcitation cardiopulmonary-cerebral rususcitation return ofspontaneous circulation|
Objective:1.Observe the influence of anisodamine plus epinephrine on coronary perfusion pressure and press end-tidal carbon dioxide and the first the total number of defibrillation shocks in swines.2.To evaluate the influence of anisodamine plus epinephrine on the return of Spontaneous Circulation (ROSC) rate and resuscitation rate of cardiac arrest swines.Methods:twenty-four swines were randomized to three groups:control group,epinephrine group and epinephrine plus anisodamine group.Cardiac arrest was induced by the electric shock of the right ventricle endometrial.In total,16domestic swines,two groups include epinephrine group and epinephrine plus anisodamine group.underwent standard manual CPR plus defibrillation plus medicine after8min of untreated ventricular ECG,AOP and RAP were recorded continously for the untreated-period and CPR.CPP was calculated as the gradient of (AOP-RAP) simultaneously. Return of spontaneous circulation rate and resuscitation rate were compared between these groups.Results:All swines were successfully venturicular fibrillation by10s sustained electric shock. The CPP of epinephrine plus anisodamin group was higher during compression than epinephrine group in55s. The ROSC rate and resuscitation rate of epinephrine plus anisodamin group was higher compared with anisodamin group(87.5%vs25%).Conclusion:Adminstration of epinephrine plus anisodamine at the beginning of cardiac arrest could improve CPP, PetCO2,defibrillation-success rate,ROSC rate and resuscitation rate.